Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy

Gain-of-function (GOF) variants in K(+) channels cause severe childhood epilepsies, but there are no mechanisms to explain how increased K(+) currents lead to network hyperexcitability. Here, we introduce a human Na(+)-activated K(+) (K(Na)) channel variant (KCNT1-Y796H) into mice and, using a multi...

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Detalles Bibliográficos
Autores principales: Shore, Amy N., Colombo, Sophie, Tobin, William F., Petri, Sabrina, Cullen, Erin R., Dominguez, Soledad, Bostick, Christopher D., Beaumont, Michael A., Williams, Damian, Khodagholy, Dion, Yang, Mu, Lutz, Cathleen M., Peng, Yueqing, Gelinas, Jennifer N., Goldstein, David B., Boland, Michael J., Frankel, Wayne N., Weston, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712469/
https://www.ncbi.nlm.nih.gov/pubmed/33113364
http://dx.doi.org/10.1016/j.celrep.2020.108303

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