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Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?

Paracoccidioidomycosis is a neglected disease that causes economic and social impacts, mainly affecting people of certain social segments, such as rural workers. The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability...

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Detalles Bibliográficos
Autores principales: do Carmo Silva, Lívia, de Oliveira, Amanda Alves, de Souza, Dienny Rodrigues, Barbosa, Katheryne Lohany Barros, Freitas e Silva, Kleber Santiago, Carvalho Júnior, Marcos Antonio Batista, Rocha, Olívia Basso, Lima, Raisa Melo, Santos, Thaynara Gonzaga, Soares, Célia Maria de Almeida, Pereira, Maristela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712482/
https://www.ncbi.nlm.nih.gov/pubmed/33228010
http://dx.doi.org/10.3390/jof6040300
Descripción
Sumario:Paracoccidioidomycosis is a neglected disease that causes economic and social impacts, mainly affecting people of certain social segments, such as rural workers. The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability in target tissues, have become evident in clinical settings. These factors, added to the fact that Paracoccidioidomycosis (PCM) therapy is a long process, lasting from months to years, emphasize the need for the research and development of new molecules. Researchers have concentrated efforts on the identification of new compounds using numerous tools and targeting important proteins from Paracoccidioides, with the emphasis on enzymatic pathways absent in humans. This review aims to discuss the aspects related to the identification of compounds, methodologies, and perspectives when proposing new antifungal agents against PCM.