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Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow
Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712484/ https://www.ncbi.nlm.nih.gov/pubmed/32365586 http://dx.doi.org/10.3390/nano10050859 |
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author | Imbir, Gabriela Mzyk, Aldona Trembecka-Wójciga, Klaudia Jasek-Gajda, Ewa Plutecka, Hanna Schirhagl, Romana Major, Roman |
author_facet | Imbir, Gabriela Mzyk, Aldona Trembecka-Wójciga, Klaudia Jasek-Gajda, Ewa Plutecka, Hanna Schirhagl, Romana Major, Roman |
author_sort | Imbir, Gabriela |
collection | PubMed |
description | Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements. |
format | Online Article Text |
id | pubmed-7712484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77124842020-12-04 Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow Imbir, Gabriela Mzyk, Aldona Trembecka-Wójciga, Klaudia Jasek-Gajda, Ewa Plutecka, Hanna Schirhagl, Romana Major, Roman Nanomaterials (Basel) Article Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements. MDPI 2020-04-29 /pmc/articles/PMC7712484/ /pubmed/32365586 http://dx.doi.org/10.3390/nano10050859 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Imbir, Gabriela Mzyk, Aldona Trembecka-Wójciga, Klaudia Jasek-Gajda, Ewa Plutecka, Hanna Schirhagl, Romana Major, Roman Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title_full | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title_fullStr | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title_full_unstemmed | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title_short | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
title_sort | polyelectrolyte multilayer films modification with ag and rgo influences platelets activation and aggregate formation under in vitro blood flow |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712484/ https://www.ncbi.nlm.nih.gov/pubmed/32365586 http://dx.doi.org/10.3390/nano10050859 |
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