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An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development

Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8–12 weeks. CRS significantly impairs a patient’s quality of life...

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Autores principales: Michalik, Michał, Samet, Alfred, Dmowska-Koroblewska, Agnieszka, Podbielska-Kubera, Adrianna, Waszczuk-Jankowska, Małgorzata, Struck-Lewicka, Wiktoria, Markuszewski, Michał J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712485/
https://www.ncbi.nlm.nih.gov/pubmed/33255995
http://dx.doi.org/10.3390/jpm10040245
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author Michalik, Michał
Samet, Alfred
Dmowska-Koroblewska, Agnieszka
Podbielska-Kubera, Adrianna
Waszczuk-Jankowska, Małgorzata
Struck-Lewicka, Wiktoria
Markuszewski, Michał J.
author_facet Michalik, Michał
Samet, Alfred
Dmowska-Koroblewska, Agnieszka
Podbielska-Kubera, Adrianna
Waszczuk-Jankowska, Małgorzata
Struck-Lewicka, Wiktoria
Markuszewski, Michał J.
author_sort Michalik, Michał
collection PubMed
description Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8–12 weeks. CRS significantly impairs a patient’s quality of life. It needs special treatment mainly focusing on preventing local infection/inflammation with corticosteroid sprays or improving sinus drainage using nasal saline irrigation. When other treatments fail, endoscopic sinus surgery is considered an effective option. According to the state-of-the-art knowledge of CRS, there is more evidence suggesting that it is more of an inflammatory disease than an infectious one. This condition is also treated as a multifactorial inflammatory disorder as it may be triggered by various factors, such as bacterial or fungal infections, airborne irritants, defects in innate immunity, or the presence of concomitant diseases. Due to the incomplete understanding of the pathological processes of CRS, there is a continuous search for new indicators that are directly related to the pathogenesis of this disease—e.g., in the field of systems biology. The studies adopting systems biology search for possible factors responsible for the disease at genetic, transcriptomic, proteomic, and metabolomic levels. The analyses of the changes in the genome, transcriptome, proteome, and metabolome may reveal the dysfunctional pathways of inflammatory regulation and provide a clear insight into the pathogenesis of this disease. Therefore, in the present paper, we have summarized the state-of-the-art knowledge of the application of systems biology in the pathology and development of CRS.
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spelling pubmed-77124852020-12-04 An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development Michalik, Michał Samet, Alfred Dmowska-Koroblewska, Agnieszka Podbielska-Kubera, Adrianna Waszczuk-Jankowska, Małgorzata Struck-Lewicka, Wiktoria Markuszewski, Michał J. J Pers Med Review Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8–12 weeks. CRS significantly impairs a patient’s quality of life. It needs special treatment mainly focusing on preventing local infection/inflammation with corticosteroid sprays or improving sinus drainage using nasal saline irrigation. When other treatments fail, endoscopic sinus surgery is considered an effective option. According to the state-of-the-art knowledge of CRS, there is more evidence suggesting that it is more of an inflammatory disease than an infectious one. This condition is also treated as a multifactorial inflammatory disorder as it may be triggered by various factors, such as bacterial or fungal infections, airborne irritants, defects in innate immunity, or the presence of concomitant diseases. Due to the incomplete understanding of the pathological processes of CRS, there is a continuous search for new indicators that are directly related to the pathogenesis of this disease—e.g., in the field of systems biology. The studies adopting systems biology search for possible factors responsible for the disease at genetic, transcriptomic, proteomic, and metabolomic levels. The analyses of the changes in the genome, transcriptome, proteome, and metabolome may reveal the dysfunctional pathways of inflammatory regulation and provide a clear insight into the pathogenesis of this disease. Therefore, in the present paper, we have summarized the state-of-the-art knowledge of the application of systems biology in the pathology and development of CRS. MDPI 2020-11-26 /pmc/articles/PMC7712485/ /pubmed/33255995 http://dx.doi.org/10.3390/jpm10040245 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michalik, Michał
Samet, Alfred
Dmowska-Koroblewska, Agnieszka
Podbielska-Kubera, Adrianna
Waszczuk-Jankowska, Małgorzata
Struck-Lewicka, Wiktoria
Markuszewski, Michał J.
An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title_full An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title_fullStr An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title_full_unstemmed An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title_short An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development
title_sort overview of the application of systems biology in an understanding of chronic rhinosinusitis (crs) development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712485/
https://www.ncbi.nlm.nih.gov/pubmed/33255995
http://dx.doi.org/10.3390/jpm10040245
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