Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer’s Disease

Alzheimer’s disease (AD) is a fatal neurodegenerative disorder caused by protein misfolding and aggregation, affecting brain function and causing dementia. Amyloid beta (Aβ), a peptide deriving from amyloid precursor protein (APP) cleavage by-and γ-secretases, is considered a pathological hallmark o...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Antaripa, Izzo, Antonella, Mollo, Nunzia, Napolitano, Filomena, Limone, Adriana, Margheri, Francesca, Mocali, Alessandra, Minopoli, Giuseppina, Lo Bianco, Alessandra, Di Maggio, Federica, D’Argenio, Valeria, Montuori, Nunzia, Lavecchia, Antonio, Sarnataro, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712490/
https://www.ncbi.nlm.nih.gov/pubmed/33207563
http://dx.doi.org/10.3390/jpm10040232

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