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Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil

Neuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. A...

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Detalles Bibliográficos
Autores principales: de Macedo, Priscila Marques, Falcão, Eduardo Mastrangelo Marinho, Freitas, Dayvison Francis Saraiva, Freitas, Andréa d’Avila, Coutinho, Ziadir Francisco, Muniz, Mauro de Medeiros, Zancopé-Oliveira, Rosely Maria, Almeida-Paes, Rodrigo, da Silva, Marcus Tulius Teixeira, do Valle, Antonio Carlos Francesconi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712492/
https://www.ncbi.nlm.nih.gov/pubmed/33233507
http://dx.doi.org/10.3390/jof6040303
Descripción
Sumario:Neuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. All cases of PCM admitted to the INI/Fiocruz from January 2007 to December 2019 were reviewed. Eight (3.9%) among 207 patients met the diagnostic criteria for NPCM. The mean age was 44.6 years and the male:female ratio was 7:1. All cases presented multifocal disease, 5 (62.5%) the chronic form and 3 (37.5%) the acute/subacute form. All patients presented the pseudotumoral pattern and 6 (75.0%) had multiple lesions in the cerebral hemispheres. Seizures and motor symptoms were the most frequent clinical manifestations (50.0%, each). The treatment of choice was sulfamethoxazole/trimethoprim (SMZ-TMP) and fluconazole, in association (87.5%). Most patients responded well to the treatment. Sequela and death occurred in one (12.5%) patient, each.