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Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden

The role of anti-nuclear autoantibody (ANA) specificities in immune complexes (IC) formation has been studied to a limited extent in SLE, and not at all in African SLE patients. We compared ANA in IC from Sudanese and Swedish SLE patients. We included 93 Sudanese and 332 Swedish SLE patients fulfill...

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Autores principales: Elbagir, Sahwa, Sohrabian, Azita, Elshafie, Amir I., Elagib, Elnour M., Mohammed, Nasr Eldeen A., Nur, Musa A. M., Svenungsson, Elisabet, Gunnarsson, Iva, Rönnelid, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712658/
https://www.ncbi.nlm.nih.gov/pubmed/33273662
http://dx.doi.org/10.1038/s41598-020-78213-5
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author Elbagir, Sahwa
Sohrabian, Azita
Elshafie, Amir I.
Elagib, Elnour M.
Mohammed, Nasr Eldeen A.
Nur, Musa A. M.
Svenungsson, Elisabet
Gunnarsson, Iva
Rönnelid, Johan
author_facet Elbagir, Sahwa
Sohrabian, Azita
Elshafie, Amir I.
Elagib, Elnour M.
Mohammed, Nasr Eldeen A.
Nur, Musa A. M.
Svenungsson, Elisabet
Gunnarsson, Iva
Rönnelid, Johan
author_sort Elbagir, Sahwa
collection PubMed
description The role of anti-nuclear autoantibody (ANA) specificities in immune complexes (IC) formation has been studied to a limited extent in SLE, and not at all in African SLE patients. We compared ANA in IC from Sudanese and Swedish SLE patients. We included 93 Sudanese and 332 Swedish SLE patients fulfilling the 1982 ACR criteria. IC were captured using C1q-coated beads. ANA specificities were quantified in sera and IC. Results were related to modified SLEDAI. Whereas serum levels of anti-Sm, anti-dsDNA and anti-ribosomal P were higher in Swedish patients, IC levels of most ANA specificities were higher among Sudanese patients. This difference was especially prominent for anti-chromatin antibodies, which remained after adjustment for age, disease duration and treatment. Total levels of C1q-binding IC correlated with levels of specific ANA in IC, with highest correlations for anti-chromatin antibodies among Sudanese patients. Whereas occurrence of anti- SSA/Ro60, anti-histone and anti-U1RNP in both serum and IC associated with high SLEDAI score, anti-dsDNA in IC but not in serum associated with high SLEDAI. ANA, especially antibodies targeting chromatin, accumulate more in IC from Sudanese SLE patients. If the autoantibody fraction forming IC is pathogenically important, this might explain the generally described severe SLE in black populations.
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spelling pubmed-77126582020-12-03 Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden Elbagir, Sahwa Sohrabian, Azita Elshafie, Amir I. Elagib, Elnour M. Mohammed, Nasr Eldeen A. Nur, Musa A. M. Svenungsson, Elisabet Gunnarsson, Iva Rönnelid, Johan Sci Rep Article The role of anti-nuclear autoantibody (ANA) specificities in immune complexes (IC) formation has been studied to a limited extent in SLE, and not at all in African SLE patients. We compared ANA in IC from Sudanese and Swedish SLE patients. We included 93 Sudanese and 332 Swedish SLE patients fulfilling the 1982 ACR criteria. IC were captured using C1q-coated beads. ANA specificities were quantified in sera and IC. Results were related to modified SLEDAI. Whereas serum levels of anti-Sm, anti-dsDNA and anti-ribosomal P were higher in Swedish patients, IC levels of most ANA specificities were higher among Sudanese patients. This difference was especially prominent for anti-chromatin antibodies, which remained after adjustment for age, disease duration and treatment. Total levels of C1q-binding IC correlated with levels of specific ANA in IC, with highest correlations for anti-chromatin antibodies among Sudanese patients. Whereas occurrence of anti- SSA/Ro60, anti-histone and anti-U1RNP in both serum and IC associated with high SLEDAI score, anti-dsDNA in IC but not in serum associated with high SLEDAI. ANA, especially antibodies targeting chromatin, accumulate more in IC from Sudanese SLE patients. If the autoantibody fraction forming IC is pathogenically important, this might explain the generally described severe SLE in black populations. Nature Publishing Group UK 2020-12-03 /pmc/articles/PMC7712658/ /pubmed/33273662 http://dx.doi.org/10.1038/s41598-020-78213-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Elbagir, Sahwa
Sohrabian, Azita
Elshafie, Amir I.
Elagib, Elnour M.
Mohammed, Nasr Eldeen A.
Nur, Musa A. M.
Svenungsson, Elisabet
Gunnarsson, Iva
Rönnelid, Johan
Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title_full Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title_fullStr Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title_full_unstemmed Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title_short Accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in SLE patients from Sudan than Sweden
title_sort accumulation of antinuclear associated antibodies in circulating immune complexes is more prominent in sle patients from sudan than sweden
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712658/
https://www.ncbi.nlm.nih.gov/pubmed/33273662
http://dx.doi.org/10.1038/s41598-020-78213-5
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