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The association between body mass index and varicocele: A meta-analysis

OBJECTIVE: Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele. MATERIAL AND METHODS: We s...

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Autores principales: Xiao-Bin, Guo, Fang-Lei, Wu, Hui, Xia, Cheng, Yang, Zhi-Xuan, Cai, Zhi-Peng, Huang, Cun-Dong, Liu, Wen-Bin, Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712683/
https://www.ncbi.nlm.nih.gov/pubmed/32271509
http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0210
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author Xiao-Bin, Guo
Fang-Lei, Wu
Hui, Xia
Cheng, Yang
Zhi-Xuan, Cai
Zhi-Peng, Huang
Cun-Dong, Liu
Wen-Bin, Guo
author_facet Xiao-Bin, Guo
Fang-Lei, Wu
Hui, Xia
Cheng, Yang
Zhi-Xuan, Cai
Zhi-Peng, Huang
Cun-Dong, Liu
Wen-Bin, Guo
author_sort Xiao-Bin, Guo
collection PubMed
description OBJECTIVE: Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele. MATERIAL AND METHODS: We searched for studies in PubMed, Science Direct and the Cochrane Library from inception until February 2018. The association between BMI and varicocele was assessed by pooling the odds ratios (ORs). RESULTS: Eleven eligible studies with a total study population of 1.376.658 participants were included in our analysis. According to BMI, the subjects were defined as belonging to the obese, overweight and underweight groups. Our results showed that the obese group had a lower risk of varicocele when compared with the normal weight group (odds ratio [OR] 0.46, 95% confidence intervals [CIs] 0.37-0.58). Additionally, an overweight BMI had a protective effect against varicocele (OR 0.70, 95% CIs, 0.56-0.86). However, underweight patients had a more than 30% higher risk of varicocele (OR 1.31, 95% CI, 1.04-1.64). Furthermore, there was no publication bias in any of the analyses. CONCLUSIONS: Our study demonstrates that BMI is negatively associated with the presence of varicocele.
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spelling pubmed-77126832020-12-05 The association between body mass index and varicocele: A meta-analysis Xiao-Bin, Guo Fang-Lei, Wu Hui, Xia Cheng, Yang Zhi-Xuan, Cai Zhi-Peng, Huang Cun-Dong, Liu Wen-Bin, Guo Int Braz J Urol Review Article OBJECTIVE: Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele. MATERIAL AND METHODS: We searched for studies in PubMed, Science Direct and the Cochrane Library from inception until February 2018. The association between BMI and varicocele was assessed by pooling the odds ratios (ORs). RESULTS: Eleven eligible studies with a total study population of 1.376.658 participants were included in our analysis. According to BMI, the subjects were defined as belonging to the obese, overweight and underweight groups. Our results showed that the obese group had a lower risk of varicocele when compared with the normal weight group (odds ratio [OR] 0.46, 95% confidence intervals [CIs] 0.37-0.58). Additionally, an overweight BMI had a protective effect against varicocele (OR 0.70, 95% CIs, 0.56-0.86). However, underweight patients had a more than 30% higher risk of varicocele (OR 1.31, 95% CI, 1.04-1.64). Furthermore, there was no publication bias in any of the analyses. CONCLUSIONS: Our study demonstrates that BMI is negatively associated with the presence of varicocele. Sociedade Brasileira de Urologia 2020-11-18 /pmc/articles/PMC7712683/ /pubmed/32271509 http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0210 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xiao-Bin, Guo
Fang-Lei, Wu
Hui, Xia
Cheng, Yang
Zhi-Xuan, Cai
Zhi-Peng, Huang
Cun-Dong, Liu
Wen-Bin, Guo
The association between body mass index and varicocele: A meta-analysis
title The association between body mass index and varicocele: A meta-analysis
title_full The association between body mass index and varicocele: A meta-analysis
title_fullStr The association between body mass index and varicocele: A meta-analysis
title_full_unstemmed The association between body mass index and varicocele: A meta-analysis
title_short The association between body mass index and varicocele: A meta-analysis
title_sort association between body mass index and varicocele: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712683/
https://www.ncbi.nlm.nih.gov/pubmed/32271509
http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0210
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