Intranasal Immunization of Mice with Multiepitope Chimeric Vaccine Candidate Based on Conserved Autotransporters SigA, Pic and Sap, Confers Protection against Shigella flexneri

Shigellosis is a diarrheal disease and the World Health Organization prompts the development of a vaccine against Shigella flexneri. The autotransporters SigA, Pic and Sap are conserved among Shigella spp. We previously designed an in silico vaccine with immunodominat epitopes from those autotranspo...

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Detalles Bibliográficos
Autores principales: León, Yrvin, Zapata, Lionel, Molina, Raúl E., Okanovič, Gaj, Gómez, Leonardo A., Daza-Castro, Carla, Flores-Concha, Manuel, Reyes, José L., Oñate, Angel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712744/
https://www.ncbi.nlm.nih.gov/pubmed/33019492
http://dx.doi.org/10.3390/vaccines8040563

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