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Radiation Biomarkers in Large Scale Human Health Effects Studies
Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712754/ https://www.ncbi.nlm.nih.gov/pubmed/33023046 http://dx.doi.org/10.3390/jpm10040155 |
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author | Moquet, Jayne Rothkamm, Kai Barnard, Stephen Ainsbury, Elizabeth |
author_facet | Moquet, Jayne Rothkamm, Kai Barnard, Stephen Ainsbury, Elizabeth |
author_sort | Moquet, Jayne |
collection | PubMed |
description | Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward. |
format | Online Article Text |
id | pubmed-7712754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77127542020-12-04 Radiation Biomarkers in Large Scale Human Health Effects Studies Moquet, Jayne Rothkamm, Kai Barnard, Stephen Ainsbury, Elizabeth J Pers Med Article Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward. MDPI 2020-10-03 /pmc/articles/PMC7712754/ /pubmed/33023046 http://dx.doi.org/10.3390/jpm10040155 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moquet, Jayne Rothkamm, Kai Barnard, Stephen Ainsbury, Elizabeth Radiation Biomarkers in Large Scale Human Health Effects Studies |
title | Radiation Biomarkers in Large Scale Human Health Effects Studies |
title_full | Radiation Biomarkers in Large Scale Human Health Effects Studies |
title_fullStr | Radiation Biomarkers in Large Scale Human Health Effects Studies |
title_full_unstemmed | Radiation Biomarkers in Large Scale Human Health Effects Studies |
title_short | Radiation Biomarkers in Large Scale Human Health Effects Studies |
title_sort | radiation biomarkers in large scale human health effects studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712754/ https://www.ncbi.nlm.nih.gov/pubmed/33023046 http://dx.doi.org/10.3390/jpm10040155 |
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