Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investi...

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Autores principales: Sreter, Katherina B., Popovic-Grle, Sanja, Lampalo, Marina, Konjevod, Marcela, Tudor, Lucija, Nikolac Perkovic, Matea, Jukic, Irena, Bingulac-Popovic, Jasna, Safic Stanic, Hana, Markeljevic, Jasenka, Pivac, Nela, Svob Strac, Dubravka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712770/
https://www.ncbi.nlm.nih.gov/pubmed/33114368
http://dx.doi.org/10.3390/jpm10040189
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author Sreter, Katherina B.
Popovic-Grle, Sanja
Lampalo, Marina
Konjevod, Marcela
Tudor, Lucija
Nikolac Perkovic, Matea
Jukic, Irena
Bingulac-Popovic, Jasna
Safic Stanic, Hana
Markeljevic, Jasenka
Pivac, Nela
Svob Strac, Dubravka
author_facet Sreter, Katherina B.
Popovic-Grle, Sanja
Lampalo, Marina
Konjevod, Marcela
Tudor, Lucija
Nikolac Perkovic, Matea
Jukic, Irena
Bingulac-Popovic, Jasna
Safic Stanic, Hana
Markeljevic, Jasenka
Pivac, Nela
Svob Strac, Dubravka
author_sort Sreter, Katherina B.
collection PubMed
description Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity.
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spelling pubmed-77127702020-12-04 Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma Sreter, Katherina B. Popovic-Grle, Sanja Lampalo, Marina Konjevod, Marcela Tudor, Lucija Nikolac Perkovic, Matea Jukic, Irena Bingulac-Popovic, Jasna Safic Stanic, Hana Markeljevic, Jasenka Pivac, Nela Svob Strac, Dubravka J Pers Med Article Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity. MDPI 2020-10-24 /pmc/articles/PMC7712770/ /pubmed/33114368 http://dx.doi.org/10.3390/jpm10040189 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sreter, Katherina B.
Popovic-Grle, Sanja
Lampalo, Marina
Konjevod, Marcela
Tudor, Lucija
Nikolac Perkovic, Matea
Jukic, Irena
Bingulac-Popovic, Jasna
Safic Stanic, Hana
Markeljevic, Jasenka
Pivac, Nela
Svob Strac, Dubravka
Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title_full Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title_fullStr Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title_full_unstemmed Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title_short Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
title_sort plasma brain-derived neurotrophic factor (bdnf) concentration and bdnf/trkb gene polymorphisms in croatian adults with asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712770/
https://www.ncbi.nlm.nih.gov/pubmed/33114368
http://dx.doi.org/10.3390/jpm10040189
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