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An open-label, single-arm, phase II trial of buparlisib in patients with melanoma brain metastases not eligible for surgery or radiosurgery—the BUMPER study

BACKGROUND: Patients with melanoma brain metastasis (MBM) still carry a dismal prognosis. Preclinical data originated in xenograft models showed that buparlisib therapy was highly effective in therapy-naïve MBM. PATIENTS AND METHODS: In this open-label, phase II trial, we investigate the safety and...

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Detalles Bibliográficos
Autores principales:	Amaral, Teresa, Niessner, Heike, Sinnberg, Tobias, Thomas, Ioannis, Meiwes, Andreas, Garbe, Claus, Garzarolli, Marlene, Rauschenberg, Ricarda, Eigentler, Thomas, Meier, Friedegund
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712798/ https://www.ncbi.nlm.nih.gov/pubmed/33305271 http://dx.doi.org/10.1093/noajnl/vdaa140

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