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Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We comp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712853/ https://www.ncbi.nlm.nih.gov/pubmed/33019741 http://dx.doi.org/10.3390/jof6040202 |
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author | Sehgal, Inderpaul Singh Dhooria, Sahajal Prasad, Kuruswamy Thurai Muthu, Valliappan Sachdeva, Naresh Bhadada, Sanjay Kumar Aggarwal, Ashutosh Nath Garg, Mandeep Chakrabarti, Arunaloke Agarwal, Ritesh |
author_facet | Sehgal, Inderpaul Singh Dhooria, Sahajal Prasad, Kuruswamy Thurai Muthu, Valliappan Sachdeva, Naresh Bhadada, Sanjay Kumar Aggarwal, Ashutosh Nath Garg, Mandeep Chakrabarti, Arunaloke Agarwal, Ritesh |
author_sort | Sehgal, Inderpaul Singh |
collection | PubMed |
description | The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We compared the clinicoradiological features, microbiology, the immunological response, and the severity of CPA in those with or without vitamin D deficiency. We measured plasma vitamin D levels in 230 consecutive treatment-naïve subjects with CPA and 78 controls (28 with prior tuberculosis (TB); 50 healthy controls). We defined vitamin D deficiency as 25(OH)D3 level <20 ng/mL. The mean (95% confidence intervals (CI)) levels of plasma vitamin D levels were 19.5 (17.6–21.4), 18.6 (13.9–23.3), and 15.3 (12.6–17.9) ng/mL in subjects with CPA, diseased controls, and healthy controls, respectively; and the levels were not different between the groups. The prevalence of vitamin D deficiency in subjects with CPA was 65% (n = 150) and was also not different between healthy (70%) or diseased (61%) controls. We did not find any difference in the clinicoradiological features, microbiology, immunological response, and severity of CPA between vitamin D sufficient and deficient groups. The prevalence of vitamin D deficiency is high in subjects with CPA, albeit similar to controls. Vitamin D deficiency does not affect the disease severity in subjects with CPA. |
format | Online Article Text |
id | pubmed-7712853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77128532020-12-04 Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis Sehgal, Inderpaul Singh Dhooria, Sahajal Prasad, Kuruswamy Thurai Muthu, Valliappan Sachdeva, Naresh Bhadada, Sanjay Kumar Aggarwal, Ashutosh Nath Garg, Mandeep Chakrabarti, Arunaloke Agarwal, Ritesh J Fungi (Basel) Article The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We compared the clinicoradiological features, microbiology, the immunological response, and the severity of CPA in those with or without vitamin D deficiency. We measured plasma vitamin D levels in 230 consecutive treatment-naïve subjects with CPA and 78 controls (28 with prior tuberculosis (TB); 50 healthy controls). We defined vitamin D deficiency as 25(OH)D3 level <20 ng/mL. The mean (95% confidence intervals (CI)) levels of plasma vitamin D levels were 19.5 (17.6–21.4), 18.6 (13.9–23.3), and 15.3 (12.6–17.9) ng/mL in subjects with CPA, diseased controls, and healthy controls, respectively; and the levels were not different between the groups. The prevalence of vitamin D deficiency in subjects with CPA was 65% (n = 150) and was also not different between healthy (70%) or diseased (61%) controls. We did not find any difference in the clinicoradiological features, microbiology, immunological response, and severity of CPA between vitamin D sufficient and deficient groups. The prevalence of vitamin D deficiency is high in subjects with CPA, albeit similar to controls. Vitamin D deficiency does not affect the disease severity in subjects with CPA. MDPI 2020-10-01 /pmc/articles/PMC7712853/ /pubmed/33019741 http://dx.doi.org/10.3390/jof6040202 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sehgal, Inderpaul Singh Dhooria, Sahajal Prasad, Kuruswamy Thurai Muthu, Valliappan Sachdeva, Naresh Bhadada, Sanjay Kumar Aggarwal, Ashutosh Nath Garg, Mandeep Chakrabarti, Arunaloke Agarwal, Ritesh Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title | Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title_full | Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title_fullStr | Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title_full_unstemmed | Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title_short | Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis |
title_sort | prevalence of vitamin d deficiency in treatment-naïve subjects with chronic pulmonary aspergillosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712853/ https://www.ncbi.nlm.nih.gov/pubmed/33019741 http://dx.doi.org/10.3390/jof6040202 |
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