Cargando…

Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis

The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Sehgal, Inderpaul Singh, Dhooria, Sahajal, Prasad, Kuruswamy Thurai, Muthu, Valliappan, Sachdeva, Naresh, Bhadada, Sanjay Kumar, Aggarwal, Ashutosh Nath, Garg, Mandeep, Chakrabarti, Arunaloke, Agarwal, Ritesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712853/
https://www.ncbi.nlm.nih.gov/pubmed/33019741
http://dx.doi.org/10.3390/jof6040202
_version_ 1783618461001318400
author Sehgal, Inderpaul Singh
Dhooria, Sahajal
Prasad, Kuruswamy Thurai
Muthu, Valliappan
Sachdeva, Naresh
Bhadada, Sanjay Kumar
Aggarwal, Ashutosh Nath
Garg, Mandeep
Chakrabarti, Arunaloke
Agarwal, Ritesh
author_facet Sehgal, Inderpaul Singh
Dhooria, Sahajal
Prasad, Kuruswamy Thurai
Muthu, Valliappan
Sachdeva, Naresh
Bhadada, Sanjay Kumar
Aggarwal, Ashutosh Nath
Garg, Mandeep
Chakrabarti, Arunaloke
Agarwal, Ritesh
author_sort Sehgal, Inderpaul Singh
collection PubMed
description The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We compared the clinicoradiological features, microbiology, the immunological response, and the severity of CPA in those with or without vitamin D deficiency. We measured plasma vitamin D levels in 230 consecutive treatment-naïve subjects with CPA and 78 controls (28 with prior tuberculosis (TB); 50 healthy controls). We defined vitamin D deficiency as 25(OH)D3 level <20 ng/mL. The mean (95% confidence intervals (CI)) levels of plasma vitamin D levels were 19.5 (17.6–21.4), 18.6 (13.9–23.3), and 15.3 (12.6–17.9) ng/mL in subjects with CPA, diseased controls, and healthy controls, respectively; and the levels were not different between the groups. The prevalence of vitamin D deficiency in subjects with CPA was 65% (n = 150) and was also not different between healthy (70%) or diseased (61%) controls. We did not find any difference in the clinicoradiological features, microbiology, immunological response, and severity of CPA between vitamin D sufficient and deficient groups. The prevalence of vitamin D deficiency is high in subjects with CPA, albeit similar to controls. Vitamin D deficiency does not affect the disease severity in subjects with CPA.
format Online
Article
Text
id pubmed-7712853
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77128532020-12-04 Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis Sehgal, Inderpaul Singh Dhooria, Sahajal Prasad, Kuruswamy Thurai Muthu, Valliappan Sachdeva, Naresh Bhadada, Sanjay Kumar Aggarwal, Ashutosh Nath Garg, Mandeep Chakrabarti, Arunaloke Agarwal, Ritesh J Fungi (Basel) Article The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown. We evaluated the prevalence of vitamin D deficiency in subjects with CPA. We compared the clinicoradiological features, microbiology, the immunological response, and the severity of CPA in those with or without vitamin D deficiency. We measured plasma vitamin D levels in 230 consecutive treatment-naïve subjects with CPA and 78 controls (28 with prior tuberculosis (TB); 50 healthy controls). We defined vitamin D deficiency as 25(OH)D3 level <20 ng/mL. The mean (95% confidence intervals (CI)) levels of plasma vitamin D levels were 19.5 (17.6–21.4), 18.6 (13.9–23.3), and 15.3 (12.6–17.9) ng/mL in subjects with CPA, diseased controls, and healthy controls, respectively; and the levels were not different between the groups. The prevalence of vitamin D deficiency in subjects with CPA was 65% (n = 150) and was also not different between healthy (70%) or diseased (61%) controls. We did not find any difference in the clinicoradiological features, microbiology, immunological response, and severity of CPA between vitamin D sufficient and deficient groups. The prevalence of vitamin D deficiency is high in subjects with CPA, albeit similar to controls. Vitamin D deficiency does not affect the disease severity in subjects with CPA. MDPI 2020-10-01 /pmc/articles/PMC7712853/ /pubmed/33019741 http://dx.doi.org/10.3390/jof6040202 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sehgal, Inderpaul Singh
Dhooria, Sahajal
Prasad, Kuruswamy Thurai
Muthu, Valliappan
Sachdeva, Naresh
Bhadada, Sanjay Kumar
Aggarwal, Ashutosh Nath
Garg, Mandeep
Chakrabarti, Arunaloke
Agarwal, Ritesh
Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title_full Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title_fullStr Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title_full_unstemmed Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title_short Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis
title_sort prevalence of vitamin d deficiency in treatment-naïve subjects with chronic pulmonary aspergillosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712853/
https://www.ncbi.nlm.nih.gov/pubmed/33019741
http://dx.doi.org/10.3390/jof6040202
work_keys_str_mv AT sehgalinderpaulsingh prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT dhooriasahajal prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT prasadkuruswamythurai prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT muthuvalliappan prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT sachdevanaresh prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT bhadadasanjaykumar prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT aggarwalashutoshnath prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT gargmandeep prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT chakrabartiarunaloke prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis
AT agarwalritesh prevalenceofvitaminddeficiencyintreatmentnaivesubjectswithchronicpulmonaryaspergillosis