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Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring

Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different...

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Autores principales: Garzón, Vivian, Bustos, Rosa-Helena, G. Pinacho, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712907/
https://www.ncbi.nlm.nih.gov/pubmed/32993004
http://dx.doi.org/10.3390/jpm10040147
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author Garzón, Vivian
Bustos, Rosa-Helena
G. Pinacho, Daniel
author_facet Garzón, Vivian
Bustos, Rosa-Helena
G. Pinacho, Daniel
author_sort Garzón, Vivian
collection PubMed
description Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine.
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spelling pubmed-77129072020-12-04 Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring Garzón, Vivian Bustos, Rosa-Helena G. Pinacho, Daniel J Pers Med Review Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine. MDPI 2020-09-25 /pmc/articles/PMC7712907/ /pubmed/32993004 http://dx.doi.org/10.3390/jpm10040147 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garzón, Vivian
Bustos, Rosa-Helena
G. Pinacho, Daniel
Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title_full Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title_fullStr Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title_full_unstemmed Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title_short Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring
title_sort personalized medicine for antibiotics: the role of nanobiosensors in therapeutic drug monitoring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712907/
https://www.ncbi.nlm.nih.gov/pubmed/32993004
http://dx.doi.org/10.3390/jpm10040147
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