SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma

Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell lymphoma (DLBCL) significantly induce mitochondrial deacetylase sirtuin-3 (SIRT3) activity, disrupted mitochondrial structure, decreased mitoch...

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Detalles Bibliográficos
Autores principales: Bhalla, Kavita, Jaber, Sausan, Reagan, Kayla, Hamburg, Arielle, Underwood, Karen F., Jhajharia, Aditya, Singh, Maninder, Bhandary, Binny, Bhat, Shambhu, Nanaji, Nahid M., Hisa, Ruching, McCracken, Carrie, Creasy, Heather Huot, Lapidus, Rena G., Kingsbury, Tami, Mayer, Dirk, Polster, Brian, Gartenhaus, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712916/
https://www.ncbi.nlm.nih.gov/pubmed/33273545
http://dx.doi.org/10.1038/s41598-020-78193-6

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