Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils

The aggregation of hyperphosphorylated tau into amyloid fibrils is closely linked to the progression of Alzheimer’s disease. To gain insight into the link between amyloid structure and disease, the three-dimensional structure of tau fibrils has been studied using solid-state NMR (ssNMR) and cryogeni...

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Detalles Bibliográficos
Autores principales: Savastano, Adriana, Jaipuria, Garima, Andreas, Loren, Mandelkow, Eckhard, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712923/
https://www.ncbi.nlm.nih.gov/pubmed/33273615
http://dx.doi.org/10.1038/s41598-020-78161-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712923/
https://www.ncbi.nlm.nih.gov/pubmed/33273615
http://dx.doi.org/10.1038/s41598-020-78161-0

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