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Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series
BACKGROUND: Mycoplasma hyorhinis is an invader of the upper respiratory tract in swine that is considered to have ubiquitous distribution. It is mainly known for causing polyserositis and polyarthritis in weaned piglets, even though the mechanisms of systemic spread are not fully understood. Mycopla...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713030/ https://www.ncbi.nlm.nih.gov/pubmed/33292668 http://dx.doi.org/10.1186/s40813-020-00178-8 |
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author | Bünger, Moritz Brunthaler, Rene Unterweger, Christine Loncaric, Igor Dippel, Maximiliane Ruczizka, Ursula Schwarz, Lukas Griessler, Alfred Voglmayr, Thomas Verhovsek, Doris Ladinig, Andrea Spergser, Joachim |
author_facet | Bünger, Moritz Brunthaler, Rene Unterweger, Christine Loncaric, Igor Dippel, Maximiliane Ruczizka, Ursula Schwarz, Lukas Griessler, Alfred Voglmayr, Thomas Verhovsek, Doris Ladinig, Andrea Spergser, Joachim |
author_sort | Bünger, Moritz |
collection | PubMed |
description | BACKGROUND: Mycoplasma hyorhinis is an invader of the upper respiratory tract in swine that is considered to have ubiquitous distribution. It is mainly known for causing polyserositis and polyarthritis in weaned piglets, even though the mechanisms of systemic spread are not fully understood. Mycoplasma hyorhinis has also been associated with other diseases in pigs such as pneumonia or otitis media, but so far has not been known to cause central nervous disorders. This case series reports the isolation of Mycoplasma hyorhinis from cerebrospinal fluid and/ or meningeal swabs from piglets originating from four different piglet producing farms in Austria. CASE PRESENTATION: On farm 1, coughing, stiff movement and central nervous signs occurred in nursery piglets. Mycoplasma hyorhinis was the only pathogen isolated from meningeal swabs from two piglets showing central nervous signs. Fibrinopurulent leptomeningitis was only observed in one piglet. Only one of two nursery piglets from farm 2 showed mild central nervous signs but no histologic lesions; Mycoplasma hyorhinis was isolated from cerebrospinal fluid of the piglet with neurologic signs. Mycoplasma hyorhinis was isolated from cerebrospinal fluid of all three investigated piglets from farm 3, all of which showed central nervous signs and purulent leptomeningitis. Further, Streptococcus suis was isolated from the cerebrospinal fluid of one piglet. Fibrinopurulent leptomeningitis was detected in two piglets from farm 4 that had died overnight without showing any clinical signs and Mycoplasma hyorhinis was isolated from meningeal swabs from both piglets. CONCLUSION: While causality has yet to be proven by experimental infection and in situ detection of the pathogen in histologic sections, the findings of this study and the absence of other pathogens suggest Mycoplasma hyorhinis as a potential causative agent of meningitis in swine. |
format | Online Article Text |
id | pubmed-7713030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77130302020-12-03 Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series Bünger, Moritz Brunthaler, Rene Unterweger, Christine Loncaric, Igor Dippel, Maximiliane Ruczizka, Ursula Schwarz, Lukas Griessler, Alfred Voglmayr, Thomas Verhovsek, Doris Ladinig, Andrea Spergser, Joachim Porcine Health Manag Case Report BACKGROUND: Mycoplasma hyorhinis is an invader of the upper respiratory tract in swine that is considered to have ubiquitous distribution. It is mainly known for causing polyserositis and polyarthritis in weaned piglets, even though the mechanisms of systemic spread are not fully understood. Mycoplasma hyorhinis has also been associated with other diseases in pigs such as pneumonia or otitis media, but so far has not been known to cause central nervous disorders. This case series reports the isolation of Mycoplasma hyorhinis from cerebrospinal fluid and/ or meningeal swabs from piglets originating from four different piglet producing farms in Austria. CASE PRESENTATION: On farm 1, coughing, stiff movement and central nervous signs occurred in nursery piglets. Mycoplasma hyorhinis was the only pathogen isolated from meningeal swabs from two piglets showing central nervous signs. Fibrinopurulent leptomeningitis was only observed in one piglet. Only one of two nursery piglets from farm 2 showed mild central nervous signs but no histologic lesions; Mycoplasma hyorhinis was isolated from cerebrospinal fluid of the piglet with neurologic signs. Mycoplasma hyorhinis was isolated from cerebrospinal fluid of all three investigated piglets from farm 3, all of which showed central nervous signs and purulent leptomeningitis. Further, Streptococcus suis was isolated from the cerebrospinal fluid of one piglet. Fibrinopurulent leptomeningitis was detected in two piglets from farm 4 that had died overnight without showing any clinical signs and Mycoplasma hyorhinis was isolated from meningeal swabs from both piglets. CONCLUSION: While causality has yet to be proven by experimental infection and in situ detection of the pathogen in histologic sections, the findings of this study and the absence of other pathogens suggest Mycoplasma hyorhinis as a potential causative agent of meningitis in swine. BioMed Central 2020-12-03 /pmc/articles/PMC7713030/ /pubmed/33292668 http://dx.doi.org/10.1186/s40813-020-00178-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Bünger, Moritz Brunthaler, Rene Unterweger, Christine Loncaric, Igor Dippel, Maximiliane Ruczizka, Ursula Schwarz, Lukas Griessler, Alfred Voglmayr, Thomas Verhovsek, Doris Ladinig, Andrea Spergser, Joachim Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title | Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title_full | Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title_fullStr | Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title_full_unstemmed | Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title_short | Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
title_sort | mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713030/ https://www.ncbi.nlm.nih.gov/pubmed/33292668 http://dx.doi.org/10.1186/s40813-020-00178-8 |
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