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Size distribution of virus laden droplets from expiratory ejecta of infected subjects

For rebooting economic activities in the ongoing COVID-19 pandemic scenario, it is important to pay detailed attention to infection transfer mechanisms during interaction of people in enclosed environments. Utmost concern is the possibility of aerosol mediated infection transfer, which is largely go...

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Autores principales: Anand, S., Mayya, Y. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713050/
https://www.ncbi.nlm.nih.gov/pubmed/33273648
http://dx.doi.org/10.1038/s41598-020-78110-x
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author Anand, S.
Mayya, Y. S.
author_facet Anand, S.
Mayya, Y. S.
author_sort Anand, S.
collection PubMed
description For rebooting economic activities in the ongoing COVID-19 pandemic scenario, it is important to pay detailed attention to infection transfer mechanisms during interaction of people in enclosed environments. Utmost concern is the possibility of aerosol mediated infection transfer, which is largely governed by the size distributions of virus laden droplets, termed as virusols in this work, ejected from humans. We expand on the well-known theory of Poisson fluctuations which acts as statistical barrier against formation of virusols. Analysis suggests that for viral loads < 2 × 10(5) RNA copies/mL, often corresponding to mild-to-moderate cases of COVID-19, droplets of diameter < 20 µm at the time of emission (equivalent to ~ 10 µm desiccated residue diameter) are unlikely to be of consequence in carrying infections. Cut-off diameters below which droplets will be practically free of contamination, are presented as a function of viral loading. The median diameters of virus laden polydisperse droplet distributions will be 1.5 to 20 times higher depending upon the geometric standard deviation. The studies have implications to risk assessment as well as residence time estimates of airborne infections in indoor environments. Additionally, it will be also helpful for performance evaluation of sanitization and control technologies to mitigate infection risks in workplaces.
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spelling pubmed-77130502020-12-03 Size distribution of virus laden droplets from expiratory ejecta of infected subjects Anand, S. Mayya, Y. S. Sci Rep Article For rebooting economic activities in the ongoing COVID-19 pandemic scenario, it is important to pay detailed attention to infection transfer mechanisms during interaction of people in enclosed environments. Utmost concern is the possibility of aerosol mediated infection transfer, which is largely governed by the size distributions of virus laden droplets, termed as virusols in this work, ejected from humans. We expand on the well-known theory of Poisson fluctuations which acts as statistical barrier against formation of virusols. Analysis suggests that for viral loads < 2 × 10(5) RNA copies/mL, often corresponding to mild-to-moderate cases of COVID-19, droplets of diameter < 20 µm at the time of emission (equivalent to ~ 10 µm desiccated residue diameter) are unlikely to be of consequence in carrying infections. Cut-off diameters below which droplets will be practically free of contamination, are presented as a function of viral loading. The median diameters of virus laden polydisperse droplet distributions will be 1.5 to 20 times higher depending upon the geometric standard deviation. The studies have implications to risk assessment as well as residence time estimates of airborne infections in indoor environments. Additionally, it will be also helpful for performance evaluation of sanitization and control technologies to mitigate infection risks in workplaces. Nature Publishing Group UK 2020-12-03 /pmc/articles/PMC7713050/ /pubmed/33273648 http://dx.doi.org/10.1038/s41598-020-78110-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Anand, S.
Mayya, Y. S.
Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title_full Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title_fullStr Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title_full_unstemmed Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title_short Size distribution of virus laden droplets from expiratory ejecta of infected subjects
title_sort size distribution of virus laden droplets from expiratory ejecta of infected subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713050/
https://www.ncbi.nlm.nih.gov/pubmed/33273648
http://dx.doi.org/10.1038/s41598-020-78110-x
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