Pathway engineering in yeast for synthesizing the complex polyketide bikaverin

Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic po...

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Detalles Bibliográficos
Autores principales: Zhao, Meng, Zhao, Yu, Yao, Mingdong, Iqbal, Hala, Hu, Qi, Liu, Hong, Qiao, Bin, Li, Chun, Skovbjerg, Christine A. S., Nielsen, Jens Christian, Nielsen, Jens, Frandsen, Rasmus J. N., Yuan, Yingjin, Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713123/
https://www.ncbi.nlm.nih.gov/pubmed/33273470
http://dx.doi.org/10.1038/s41467-020-19984-3

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