Cargando…
AMPK maintains TCA cycle through sequential phosphorylation of PDHA to promote tumor metastasis
Cancer represents the leading public health problem throughout the world. Globally, about one out of six deaths is related to cancer, which is largely due to the metastatic lesions. However, there are no effective strategies for targeting cancer metastasis. Identification of the key druggable target...
Autores principales: | Cai, Zhen, Peng, Danni, Lin, Hui-Kuan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713264/ https://www.ncbi.nlm.nih.gov/pubmed/33336150 http://dx.doi.org/10.15698/cst2020.12.238 |
Ejemplares similares
-
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
por: Cai, Zhen, et al.
Publicado: (2020) -
Maintaining phagosome integrity during fungal infection: do or die?
por: Yang, Mabel, et al.
Publicado: (2020) -
Attenuating MKRN1 E3 ligase-mediated AMPKα suppression increases tolerance against metabolic stresses in mice
por: Han, Hyunji, et al.
Publicado: (2018) -
Intravital imaging tumor screen used to identify novel metastasis-blocking therapeutic targets
por: Stoletov, Konstantin, et al.
Publicado: (2018) -
To promote or inhibit glioma progression, that is the question for IL-33
por: Robbins, Stephen M., et al.
Publicado: (2020)