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Silk fibroin vascular graft: a promising tissue-engineered scaffold material for abdominal venous system replacement

No alternative tissue-engineered vascular grafts for the abdominal venous system are reported. The present study focused on the development of new tissue-engineered vascular graft using a silk-based scaffold material for abdominal venous system replacement. A rat vein, the inferior vena cava, was re...

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Detalles Bibliográficos
Autores principales: Kiritani, Sho, Kaneko, Junichi, Ito, Daisuke, Morito, Masaaki, Ishizawa, Takeaki, Akamatsu, Nobuhisa, Tanaka, Mariko, Iida, Takuya, Tanaka, Takashi, Tanaka, Ryo, Asakura, Tetsuo, Arita, Junichi, Hasegawa, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713399/
https://www.ncbi.nlm.nih.gov/pubmed/33273511
http://dx.doi.org/10.1038/s41598-020-78020-y
Descripción
Sumario:No alternative tissue-engineered vascular grafts for the abdominal venous system are reported. The present study focused on the development of new tissue-engineered vascular graft using a silk-based scaffold material for abdominal venous system replacement. A rat vein, the inferior vena cava, was replaced by a silk fibroin (SF, a biocompatible natural insoluble protein present in silk thread), tissue-engineered vascular graft (10 mm long, 3 mm diameter, n = 19, SF group). The 1 and 4 -week patency rates and histologic reactions were compared with those of expanded polytetrafluoroethylene vascular grafts (n = 10, ePTFE group). The patency rate at 1 and 4 weeks after replacement in the SF group was 100.0% and 94.7%, and that in the ePTFE group was 100.0% and 80.0%, respectively. There was no significant difference between groups (p = 0.36). Unlike the ePTFE graft, CD31-positive endothelial cells covered the whole luminal surface of the SF vascular graft at 4 weeks, indicating better endothelialization. SF vascular grafts may be a promising tissue-engineered scaffold material for abdominal venous system replacement.