Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology

SARS-CoV-2, the virus causing the current COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respiratory distress syndrome. Clinical studies in recent months have revealed that COVID-19 is a multi-organ disease causing characteristic complications. Stem cell mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Simoneau, Camille R., Ott, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713543/
https://www.ncbi.nlm.nih.gov/pubmed/33275899
http://dx.doi.org/10.1016/j.stem.2020.11.012
_version_ 1783618582047883264
author Simoneau, Camille R.
Ott, Melanie
author_facet Simoneau, Camille R.
Ott, Melanie
author_sort Simoneau, Camille R.
collection PubMed
description SARS-CoV-2, the virus causing the current COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respiratory distress syndrome. Clinical studies in recent months have revealed that COVID-19 is a multi-organ disease causing characteristic complications. Stem cell models of various organ systems—most prominently, lung, gut, heart, and brain—are at the forefront of studies aimed at understanding the role of direct infection in COVID-19 multi-organ dysfunction.
format Online
Article
Text
id pubmed-7713543
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-77135432020-12-04 Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology Simoneau, Camille R. Ott, Melanie Cell Stem Cell Minireview SARS-CoV-2, the virus causing the current COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respiratory distress syndrome. Clinical studies in recent months have revealed that COVID-19 is a multi-organ disease causing characteristic complications. Stem cell models of various organ systems—most prominently, lung, gut, heart, and brain—are at the forefront of studies aimed at understanding the role of direct infection in COVID-19 multi-organ dysfunction. Published by Elsevier Inc. 2020-12-03 2020-12-03 /pmc/articles/PMC7713543/ /pubmed/33275899 http://dx.doi.org/10.1016/j.stem.2020.11.012 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Minireview
Simoneau, Camille R.
Ott, Melanie
Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title_full Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title_fullStr Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title_full_unstemmed Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title_short Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
title_sort modeling multi-organ infection by sars-cov-2 using stem cell technology
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713543/
https://www.ncbi.nlm.nih.gov/pubmed/33275899
http://dx.doi.org/10.1016/j.stem.2020.11.012
work_keys_str_mv AT simoneaucamiller modelingmultiorganinfectionbysarscov2usingstemcelltechnology
AT ottmelanie modelingmultiorganinfectionbysarscov2usingstemcelltechnology

Ejemplares similares