Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers

The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy. In our study, we used the 4‐(4‐methylpiperazin‐1‐yl)aniline molecule, previou...

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Detalles Bibliográficos
Autores principales: Pomeislová, Alice, Vrzal, Lukáš, Kozák, Jaroslav, Dobiaš, Juraj, Hubálek, Martin, Dvořáková, Hana, Reyes‐Gutiérrez, Paul E., Teplý, Filip, Veverka, Václav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713561/
https://www.ncbi.nlm.nih.gov/pubmed/33304739
http://dx.doi.org/10.1002/open.202000261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713561/
https://www.ncbi.nlm.nih.gov/pubmed/33304739
http://dx.doi.org/10.1002/open.202000261

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