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A semi-compartmental model describing the pharmacokinetic-pharmacodynamic relationship
Frequently, we encounter the phenomenon of hysteresis in kinetic-dynamic modeling. The hysteresis loop in the concentration-effect curve suggests a time discrepancy caused by various pharmacokinetic and pharmacodynamic factors. To collapse the hysteresis loop and to simplify the concentration-effect...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Korean Society of Anesthesiologists
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713860/ https://www.ncbi.nlm.nih.gov/pubmed/33329783 http://dx.doi.org/10.17085/apm.2020.15.1.1 |