CYP46A1-dependent and independent effects of efavirenz treatment

Cholesterol excess in the brain is mainly disposed via cholesterol 24-hydroxylation catalysed by cytochrome P450 46A1, a CNS-specific enzyme. Cytochrome P450 46A1 is emerging as a promising therapeutic target for various brain diseases with both enzyme activation and inhibition having therapeutic po...

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Detalles Bibliográficos
Autores principales: Mast, Natalia, El-Darzi, Nicole, Petrov, Alexey M, Li, Young, Pikuleva, Irina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713991/
https://www.ncbi.nlm.nih.gov/pubmed/33305262
http://dx.doi.org/10.1093/braincomms/fcaa180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713991/
https://www.ncbi.nlm.nih.gov/pubmed/33305262
http://dx.doi.org/10.1093/braincomms/fcaa180

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