Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2 proton...

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Detalles Bibliográficos
Autores principales: Shaw, Joseph, Gosain, Rajendra, Kalita, Monoj Mon, Foster, Toshana L, Kankanala, Jayakanth, Mahato, D Ram, Abas, Sonia, King, Barnabas J, Scott, Claire, Brown, Emma, Bentham, Matthew J, Wetherill, Laura, Bloy, Abigail, Samson, Adel, Harris, Mark, Mankouri, Jamel, Rowlands, David J, Macdonald, Andrew, Tarr, Alexander W, Fischer, Wolfgang B, Foster, Richard, Griffin, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714397/
https://www.ncbi.nlm.nih.gov/pubmed/33169665
http://dx.doi.org/10.7554/eLife.52555

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