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MIR448 antagomir reduces arrhythmic risk after myocardial infarction by upregulating the cardiac sodium channel
Cardiac ischemia is associated with arrhythmias; however, effective therapies are currently limited. The cardiac voltage-gated sodium channel α subunit (SCN5A), encoding the Na(v)1.5 current, plays a key role in the cardiac electrical conduction and arrhythmic risk. Here, we show that hypoxia reduce...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714400/ https://www.ncbi.nlm.nih.gov/pubmed/33108349 http://dx.doi.org/10.1172/jci.insight.140759 |