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Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models
We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficac...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714406/ https://www.ncbi.nlm.nih.gov/pubmed/33090972 http://dx.doi.org/10.1172/jci.insight.143174 |
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author | Rosenke, Kyle Jarvis, Michael A. Feldmann, Friederike Schwarz, Benjamin Okumura, Atsushi Lovaglio, Jamie Saturday, Greg Hanley, Patrick W. Meade-White, Kimberly Williamson, Brandi N. Hansen, Frederick Perez-Perez, Lizette Leventhal, Shanna Tang-Huau, Tsing-Lee Callison, Julie Haddock, Elaine Stromberg, Kaitlin A. Scott, Dana Sewell, Graham Bosio, Catharine M. Hawman, David de Wit, Emmie Feldmann, Heinz |
author_facet | Rosenke, Kyle Jarvis, Michael A. Feldmann, Friederike Schwarz, Benjamin Okumura, Atsushi Lovaglio, Jamie Saturday, Greg Hanley, Patrick W. Meade-White, Kimberly Williamson, Brandi N. Hansen, Frederick Perez-Perez, Lizette Leventhal, Shanna Tang-Huau, Tsing-Lee Callison, Julie Haddock, Elaine Stromberg, Kaitlin A. Scott, Dana Sewell, Graham Bosio, Catharine M. Hawman, David de Wit, Emmie Feldmann, Heinz |
author_sort | Rosenke, Kyle |
collection | PubMed |
description | We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in 2 animal disease models. The standard human malaria HCQ prophylaxis (6.5 mg/kg given weekly) and treatment (6.5 mg/kg given daily) did not significantly benefit clinical outcome, nor did it reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. Similarly, when used for prophylaxis or treatment, neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Results from these 2 preclinical animal models may prove helpful in guiding clinical use of HCQ for prophylaxis/treatment of COVID-19. |
format | Online Article Text |
id | pubmed-7714406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-77144062020-12-08 Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models Rosenke, Kyle Jarvis, Michael A. Feldmann, Friederike Schwarz, Benjamin Okumura, Atsushi Lovaglio, Jamie Saturday, Greg Hanley, Patrick W. Meade-White, Kimberly Williamson, Brandi N. Hansen, Frederick Perez-Perez, Lizette Leventhal, Shanna Tang-Huau, Tsing-Lee Callison, Julie Haddock, Elaine Stromberg, Kaitlin A. Scott, Dana Sewell, Graham Bosio, Catharine M. Hawman, David de Wit, Emmie Feldmann, Heinz JCI Insight Research Article We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in 2 animal disease models. The standard human malaria HCQ prophylaxis (6.5 mg/kg given weekly) and treatment (6.5 mg/kg given daily) did not significantly benefit clinical outcome, nor did it reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. Similarly, when used for prophylaxis or treatment, neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Results from these 2 preclinical animal models may prove helpful in guiding clinical use of HCQ for prophylaxis/treatment of COVID-19. American Society for Clinical Investigation 2020-12-03 /pmc/articles/PMC7714406/ /pubmed/33090972 http://dx.doi.org/10.1172/jci.insight.143174 Text en © 2020 Rosenke et al. http://creativecommons.org/licenses/by/4.0/ This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Rosenke, Kyle Jarvis, Michael A. Feldmann, Friederike Schwarz, Benjamin Okumura, Atsushi Lovaglio, Jamie Saturday, Greg Hanley, Patrick W. Meade-White, Kimberly Williamson, Brandi N. Hansen, Frederick Perez-Perez, Lizette Leventhal, Shanna Tang-Huau, Tsing-Lee Callison, Julie Haddock, Elaine Stromberg, Kaitlin A. Scott, Dana Sewell, Graham Bosio, Catharine M. Hawman, David de Wit, Emmie Feldmann, Heinz Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title | Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title_full | Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title_fullStr | Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title_full_unstemmed | Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title_short | Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models |
title_sort | hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster sars-cov-2 disease models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714406/ https://www.ncbi.nlm.nih.gov/pubmed/33090972 http://dx.doi.org/10.1172/jci.insight.143174 |
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