Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic–induced necroptosis

Caspase-8 (CASP8) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCCs), and CASP8 mutations are associated with poor survival. The distribution of these mutations in HNSCCs suggests that they are likely to be inactivating. Inhibition of CASP8 has been reported to...

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Detalles Bibliográficos
Autores principales: Uzunparmak, Burak, Gao, Meng, Lindemann, Antje, Erikson, Kelly, Wang, Li, Lin, Eric, Frank, Steven J., Gleber-Netto, Frederico O., Zhao, Mei, Skinner, Heath D., Newton, Jared, Sikora, Andrew G., Myers, Jeffrey N., Pickering, Curtis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714407/
https://www.ncbi.nlm.nih.gov/pubmed/33108350
http://dx.doi.org/10.1172/jci.insight.139837

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