The SWI/SNF ATPase BRG1 stimulates DNA end resection and homologous recombination by reducing nucleosome density at DNA double strand breaks and by promoting the recruitment of the CtIP nuclease

DNA double strand breaks (DSBs) are among the most toxic DNA lesions and can be repaired accurately through homologous recombination (HR). HR requires processing of the DNA ends by nucleases (DNA end resection) in order to generate the required single-stranded DNA (ssDNA) regions. The SWI/SNF chroma...

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Detalles Bibliográficos
Autores principales: Hays, Emily, Nettleton, Elizabeth, Carter, Caitlin, Morales, Mariangel, Vo, Lynn, Passo, Max, Vélez-Cruz, Renier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714457/
https://www.ncbi.nlm.nih.gov/pubmed/33044911
http://dx.doi.org/10.1080/15384101.2020.1831256

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