Cargando…

Network Pharmacology-Based Study on the Mechanism of Gegen Qinlian Decoction against Colorectal Cancer

PURPOSE: Gegen Qinlian decoction (GQD) has been used to treat gastrointestinal diseases, such as diarrhea and ulcerative colitis (UC). A recent study demonstrated that GQD enhanced the effect of PD-1 blockade in colorectal cancer (CRC). This study used network pharmacology analysis to investigate th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Qiaowei, Guo, Lin, Guan, Jingming, Chen, Jing, Fan, Yujing, Chen, Zhendong, Li, Hulun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714584/ https://www.ncbi.nlm.nih.gov/pubmed/33294000 http://dx.doi.org/10.1155/2020/8897879

Ejemplares similares

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction
por: Lu, Jing-Ze, et al.
Publicado: (2021)

The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology
por: Lin, Xiang, et al.
Publicado: (2022)

Network Pharmacology–Based Analysis and Experimental Exploration of Antidiabetic Mechanisms of Gegen Qinlian Decoction
por: Xu, Yu, et al.
Publicado: (2021)

Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation
por: Bao, Weiping, et al.
Publicado: (2022)

Based on Network Pharmacology to Explore the Molecular Targets and Mechanisms of Gegen Qinlian Decoction for the Treatment of Ulcerative Colitis
por: Wei, Meiqi, et al.
Publicado: (2020)

Integrated Pharmacology Reveals the Molecular Mechanism of Gegen Qinlian Decoction Against Lipopolysaccharide-induced Acute Lung Injury
por: Li, Wei, et al.
Publicado: (2022)

Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice
por: Han, Jing, et al.
Publicado: (2017)

Exploration of the Mechanism of the Control of Coccidiosis in Chickens Based on Network Pharmacology and Molecular Docking With the Addition of Modified Gegen Qinlian Decoction
por: Peng, Xiaomin, et al.
Publicado: (2022)

Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Gegen Qinlian Decoction for Rotavirus Enteritis
por: Zhong, Peicheng, et al.
Publicado: (2020)

In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
por: Liu, Xiaolu, et al.
Publicado: (2021)

Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota
por: Li, Yang, et al.
Publicado: (2020)

Gegen Qinlian Decoction treatment of asymptomatic hyperuricemia by targeting circadian immune function
por: Wang, Xiaojun, et al.
Publicado: (2023)

Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
por: Huang, Jinke, et al.
Publicado: (2022)

Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon
por: Lu, Xue, et al.
Publicado: (2023)

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review
por: Li, Lin-zi, et al.
Publicado: (2023)

Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway
por: Wang, Xiao-Jun, et al.
Publicado: (2021)

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis
por: Wang, Dan, et al.
Publicado: (2022)

Efficacy of herbal medicine (Gegen Qinlian Decoction) on ulcerative colitis: A systematic review of randomized controlled trials
por: Fan, Yuling, et al.
Publicado: (2019)

Gegen Qinlian Decoction Relieves Ulcerative Colitis via Adjusting Dysregulated Nrf2/ARE Signaling
por: Lin, Chuan, et al.
Publicado: (2022)

Focal Microscopy Observe the Mechanism of Gegen Qinlian Decoction Treating Type 2 Diabetic Nephropathy in Nude Mice
por: Zheng, Fei, et al.
Publicado: (2022)

Gegen Qinlian Decoction Treats Diarrhea in Piglets by Modulating Gut Microbiota and Short-Chain Fatty Acids
por: Liu, Chang-Shun, et al.
Publicado: (2019)

Tissue distribution and integrated pharmacokinetic properties of major effective constituents of oral Gegen-Qinlian decoction in mice
por: Lu, Jing-Ze, et al.
Publicado: (2022)

Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine
por: Xu, Xizhan, et al.
Publicado: (2020)

Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway
por: Li, Feng, et al.
Publicado: (2022)

Gegen Qinlian Decoction Attenuates High-Fat Diet-Induced Steatohepatitis in Rats via Gut Microbiota
por: Guo, Yi, et al.
Publicado: (2018)

Metformin and Gegen Qinlian Decoction boost islet α-cell proliferation of the STZ induced diabetic rats
por: Xu, Li, et al.
Publicado: (2022)

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids
por: Wang, Xue, et al.
Publicado: (2023)

Retracted: Focal Microscopy Observe the Mechanism of Gegen Qinlian Decoction Treating Type 2 Diabetic Nephropathy in Nude Mice
por: International, BioMed Research
Publicado: (2023)

Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment
por: Lv, Ji, et al.
Publicado: (2019)

Gegen Qinlian Decoction combined with Metformin for the treatment of patients with Type-2 Diabetes Mellitus: A retrospective observational study
por: Chen, Yingqi, et al.
Publicado: (2023)

Administration of modified Gegen Qinlian decoction for hemorrhagic chronic radiation proctitis: A case report and review of literature
por: Liu, Shao-Yong, et al.
Publicado: (2023)

Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination
por: Chen, Jiamei, et al.
Publicado: (2023)

Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials
por: Ren, Lin, et al.
Publicado: (2020)

Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1)
por: Sui, Miao, et al.
Publicado: (2019)

Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula
por: Qiao, Xue, et al.
Publicado: (2016)

Gegen Qinlian Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats via Oxidative Stress, Inflammation, and the NLRP3 Signal Axis
por: Ying, Yuqi, et al.
Publicado: (2021)

Gegen Qinlian Decoction Alleviates Experimental Colitis and Concurrent Lung Inflammation by Inhibiting the Recruitment of Inflammatory Myeloid Cells and Restoring Microbial Balance
por: Li, Yalan, et al.
Publicado: (2022)

Modified Gegen Qinlian Decoction Regulates Treg/Th17 Balance to Ameliorate DSS-Induced Acute Experimental Colitis in Mice by Altering the Gut Microbiota
por: Wang, Yifan, et al.
Publicado: (2021)

A 42-Markers Pharmacokinetic Study Reveals Interactions of Berberine and Glycyrrhizic Acid in the Anti-diabetic Chinese Medicine Formula Gegen-Qinlian Decoction
por: Qiao, Xue, et al.
Publicado: (2018)

The effect of Gegen Qinlian Decoction on clinical prognosis and islet function for type 2 diabetic mellitus: A protocol for systematic review and meta-analysis
por: Ren, Yuhang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r431encvkc806t9jraucf1pk5m