Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer

Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Xiaodong, Zhang, Zhijun, Sun, Peng, Song, Guanghui, Wang, Lu, Sun, Zhenqing, Yuan, Ning, Wang, Qing, Lun, Limin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714607/
https://www.ncbi.nlm.nih.gov/pubmed/33294056
http://dx.doi.org/10.1155/2020/6439614
_version_ 1783618779286077440
author Feng, Xiaodong
Zhang, Zhijun
Sun, Peng
Song, Guanghui
Wang, Lu
Sun, Zhenqing
Yuan, Ning
Wang, Qing
Lun, Limin
author_facet Feng, Xiaodong
Zhang, Zhijun
Sun, Peng
Song, Guanghui
Wang, Lu
Sun, Zhenqing
Yuan, Ning
Wang, Qing
Lun, Limin
author_sort Feng, Xiaodong
collection PubMed
description Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P = 0.001) and American Joint Committee on Cancer (AJCC) stage (P = 0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.
format Online
Article
Text
id pubmed-7714607
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-77146072020-12-07 Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer Feng, Xiaodong Zhang, Zhijun Sun, Peng Song, Guanghui Wang, Lu Sun, Zhenqing Yuan, Ning Wang, Qing Lun, Limin Dis Markers Research Article Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P = 0.001) and American Joint Committee on Cancer (AJCC) stage (P = 0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients. Hindawi 2020-11-26 /pmc/articles/PMC7714607/ /pubmed/33294056 http://dx.doi.org/10.1155/2020/6439614 Text en Copyright © 2020 Xiaodong Feng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Xiaodong
Zhang, Zhijun
Sun, Peng
Song, Guanghui
Wang, Lu
Sun, Zhenqing
Yuan, Ning
Wang, Qing
Lun, Limin
Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_full Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_fullStr Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_full_unstemmed Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_short Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_sort interleukin-18 is a prognostic marker and plays a tumor suppressive role in colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714607/
https://www.ncbi.nlm.nih.gov/pubmed/33294056
http://dx.doi.org/10.1155/2020/6439614
work_keys_str_mv AT fengxiaodong interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT zhangzhijun interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT sunpeng interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT songguanghui interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT wanglu interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT sunzhenqing interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT yuanning interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT wangqing interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
AT lunlimin interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer

Ejemplares similares