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Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia
People with schizophrenia exhibit increased intra-individual variability in both behavioral and neural signatures of cognition. Examination of intra-individual variability may uncover a unique functionally relevant aspect of impairment that is not captured by typical between-group comparisons of mea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714716/ https://www.ncbi.nlm.nih.gov/pubmed/33329084 http://dx.doi.org/10.3389/fpsyt.2020.543963 |
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author | Fradkin, Samantha I. Erickson, Molly A. Demmin, Docia L. Silverstein, Steven M. |
author_facet | Fradkin, Samantha I. Erickson, Molly A. Demmin, Docia L. Silverstein, Steven M. |
author_sort | Fradkin, Samantha I. |
collection | PubMed |
description | People with schizophrenia exhibit increased intra-individual variability in both behavioral and neural signatures of cognition. Examination of intra-individual variability may uncover a unique functionally relevant aspect of impairment that is not captured by typical between-group comparisons of mean or median values. We and others have observed that retinal activity measured using electroretinography (ERG) is significantly reduced in people with schizophrenia; however, it is currently unclear whether greater intra-individual variability in the retinal response can also be observed. To investigate this, we examined intra-individual variability from 25 individuals with schizophrenia and 24 healthy controls under two fERG conditions: (1) a light-adapted condition in which schizophrenia patients demonstrated reduced amplitudes; and (2) a dark-adapted condition in which the groups did not differ in amplitudes. Intraclass correlation coefficients (ICC) were generated to measure intra-individual variability for each subject, reflecting the consistency of activation values (in μv) across all sampling points (at a 2 kHz sampling rate) within all trials within a condition. Contrary to our predictions, results indicated that the schizophrenia and healthy control groups did not differ in intra-individual variability in fERG responses in either the light- or dark-adapted conditions. This finding remained consistent when variability was calculated as the standard deviation (SD) and coefficient of variation (CV) of maximum positive and negative microvolt values within the a- and b-wave time windows. This suggests that although elevated variability in schizophrenia may be observed at perceptual and cognitive levels of processing, it is not present in the earliest stages of sensory processing in vision. |
format | Online Article Text |
id | pubmed-7714716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77147162020-12-15 Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia Fradkin, Samantha I. Erickson, Molly A. Demmin, Docia L. Silverstein, Steven M. Front Psychiatry Psychiatry People with schizophrenia exhibit increased intra-individual variability in both behavioral and neural signatures of cognition. Examination of intra-individual variability may uncover a unique functionally relevant aspect of impairment that is not captured by typical between-group comparisons of mean or median values. We and others have observed that retinal activity measured using electroretinography (ERG) is significantly reduced in people with schizophrenia; however, it is currently unclear whether greater intra-individual variability in the retinal response can also be observed. To investigate this, we examined intra-individual variability from 25 individuals with schizophrenia and 24 healthy controls under two fERG conditions: (1) a light-adapted condition in which schizophrenia patients demonstrated reduced amplitudes; and (2) a dark-adapted condition in which the groups did not differ in amplitudes. Intraclass correlation coefficients (ICC) were generated to measure intra-individual variability for each subject, reflecting the consistency of activation values (in μv) across all sampling points (at a 2 kHz sampling rate) within all trials within a condition. Contrary to our predictions, results indicated that the schizophrenia and healthy control groups did not differ in intra-individual variability in fERG responses in either the light- or dark-adapted conditions. This finding remained consistent when variability was calculated as the standard deviation (SD) and coefficient of variation (CV) of maximum positive and negative microvolt values within the a- and b-wave time windows. This suggests that although elevated variability in schizophrenia may be observed at perceptual and cognitive levels of processing, it is not present in the earliest stages of sensory processing in vision. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7714716/ /pubmed/33329084 http://dx.doi.org/10.3389/fpsyt.2020.543963 Text en Copyright © 2020 Fradkin, Erickson, Demmin and Silverstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Fradkin, Samantha I. Erickson, Molly A. Demmin, Docia L. Silverstein, Steven M. Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title | Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title_full | Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title_fullStr | Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title_full_unstemmed | Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title_short | Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia |
title_sort | absence of excess intra-individual variability in retinal function in people with schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714716/ https://www.ncbi.nlm.nih.gov/pubmed/33329084 http://dx.doi.org/10.3389/fpsyt.2020.543963 |
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