Evaluation of [(13)N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain

PURPOSE: The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glutamate to glutamine requires ammonia, we evaluated whether [(1...

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Detalles Bibliográficos
Autores principales: Egerton, Alice, Dunn, Joel T., Singh, Nisha, Yu, Zilin, O’Doherty, Jim, Koychev, Ivan, Webb, Jessica, Claridge, Simon, Turkheimer, Federico E., Marsden, Paul K., Hammers, Alexander, Gee, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714883/
https://www.ncbi.nlm.nih.gov/pubmed/33270177
http://dx.doi.org/10.1186/s13550-020-00731-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714883/
https://www.ncbi.nlm.nih.gov/pubmed/33270177
http://dx.doi.org/10.1186/s13550-020-00731-0

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