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‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation

PURPOSE: To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes. METHODS: A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital...

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Autores principales: Coccia, Maria Elisabetta, Rizzello, Francesca, Wakunga, Savio, Badolato, Laura, Evangelisti, Paolo, Bertocci, Francesco, Claudia, Giachini, Criscuoli, Luciana, Micelli, Elisabetta, Picone, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714895/
https://www.ncbi.nlm.nih.gov/pubmed/33047185
http://dx.doi.org/10.1007/s10815-020-01961-w
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author Coccia, Maria Elisabetta
Rizzello, Francesca
Wakunga, Savio
Badolato, Laura
Evangelisti, Paolo
Bertocci, Francesco
Claudia, Giachini
Criscuoli, Luciana
Micelli, Elisabetta
Picone, Rita
author_facet Coccia, Maria Elisabetta
Rizzello, Francesca
Wakunga, Savio
Badolato, Laura
Evangelisti, Paolo
Bertocci, Francesco
Claudia, Giachini
Criscuoli, Luciana
Micelli, Elisabetta
Picone, Rita
author_sort Coccia, Maria Elisabetta
collection PubMed
description PURPOSE: To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes. METHODS: A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital of Florence, Italy. The study population included 622 consecutive donor oocyte cycles. A mean number of 6 vitrified oocytes per couple were shipped from two Spanish biobanks. In the receiving centre, gametes were warmed and inseminated and the subsequent embryo transfer (ET) was performed. The main outcome measurement was LBR. Secondary outcomes included oocyte survival rate, ICSI damage rate, normal fertilization, cleavage, and implantation rate (IR) in both ‘fresh’ and cryotransfer cycles. RESULTS: A total number of 3536 mature oocytes were warmed with 81.4% surviving oocytes. 2PN oocytes were 1941 with an ICSI normal fertilization rate of 70.4% and a cleavage rate of 93.4%; 857 day-3 embryos were transferred in 498 women, 63 blastocysts in 44. Couples with at least one vitrified embryo were 181 (32.3%). IR was 25.1% and 33.1% for day-3 ET and blastocyst stage respectively. Crude pregnancy rate and LBR after the first ET were 35.5% and 27% correspondingly with a conservative cumulative LBR of 34% and an optimal LBR of 51.4%. CONCLUSION: Imported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10815-020-01961-w) contains supplementary material, which is available to authorized users.
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spelling pubmed-77148952020-12-07 ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation Coccia, Maria Elisabetta Rizzello, Francesca Wakunga, Savio Badolato, Laura Evangelisti, Paolo Bertocci, Francesco Claudia, Giachini Criscuoli, Luciana Micelli, Elisabetta Picone, Rita J Assist Reprod Genet Assisted Reproduction Technologies PURPOSE: To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes. METHODS: A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital of Florence, Italy. The study population included 622 consecutive donor oocyte cycles. A mean number of 6 vitrified oocytes per couple were shipped from two Spanish biobanks. In the receiving centre, gametes were warmed and inseminated and the subsequent embryo transfer (ET) was performed. The main outcome measurement was LBR. Secondary outcomes included oocyte survival rate, ICSI damage rate, normal fertilization, cleavage, and implantation rate (IR) in both ‘fresh’ and cryotransfer cycles. RESULTS: A total number of 3536 mature oocytes were warmed with 81.4% surviving oocytes. 2PN oocytes were 1941 with an ICSI normal fertilization rate of 70.4% and a cleavage rate of 93.4%; 857 day-3 embryos were transferred in 498 women, 63 blastocysts in 44. Couples with at least one vitrified embryo were 181 (32.3%). IR was 25.1% and 33.1% for day-3 ET and blastocyst stage respectively. Crude pregnancy rate and LBR after the first ET were 35.5% and 27% correspondingly with a conservative cumulative LBR of 34% and an optimal LBR of 51.4%. CONCLUSION: Imported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10815-020-01961-w) contains supplementary material, which is available to authorized users. Springer US 2020-10-12 2020-12 /pmc/articles/PMC7714895/ /pubmed/33047185 http://dx.doi.org/10.1007/s10815-020-01961-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Assisted Reproduction Technologies
Coccia, Maria Elisabetta
Rizzello, Francesca
Wakunga, Savio
Badolato, Laura
Evangelisti, Paolo
Bertocci, Francesco
Claudia, Giachini
Criscuoli, Luciana
Micelli, Elisabetta
Picone, Rita
‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title_full ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title_fullStr ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title_full_unstemmed ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title_short ‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation
title_sort ‘two countries-two labs’: the transnational gamete donation (tgd) programme to support egg donation
topic Assisted Reproduction Technologies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714895/
https://www.ncbi.nlm.nih.gov/pubmed/33047185
http://dx.doi.org/10.1007/s10815-020-01961-w
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