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Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries
Aim: We investigated the antioxidant protective power of egg white hydrolysate (EWH) against the vascular damage induced by mercury chloride (HgCl(2)) exposure in resistance arteries. Methods: Male Wistar rats received for 60 days: (I) intramuscular injections (i.m.) of saline and tap water by gavag...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714919/ https://www.ncbi.nlm.nih.gov/pubmed/33329045 http://dx.doi.org/10.3389/fphys.2020.595767 |
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author | Escobar, Alyne Goulart Rizzetti, Danize Aparecida Piagette, Janaina Trindade Peçanha, Franck Maciel Vassallo, Dalton Valentim Miguel, Marta Wiggers, Giulia Alessandra |
author_facet | Escobar, Alyne Goulart Rizzetti, Danize Aparecida Piagette, Janaina Trindade Peçanha, Franck Maciel Vassallo, Dalton Valentim Miguel, Marta Wiggers, Giulia Alessandra |
author_sort | Escobar, Alyne Goulart |
collection | PubMed |
description | Aim: We investigated the antioxidant protective power of egg white hydrolysate (EWH) against the vascular damage induced by mercury chloride (HgCl(2)) exposure in resistance arteries. Methods: Male Wistar rats received for 60 days: (I) intramuscular injections (i.m.) of saline and tap water by gavage – Untreated group; (II) 4.6 μg/kg of HgCl(2) i.m. for the first dose and subsequent doses of 0.07 μg/kg/day and tap water by gavage – HgCl(2) group; (III) saline i.m. and 1 g/kg/day of EWH by gavage – EWH group, or (IV) the combination of the HgCl(2) i.m. and EWH by gavage – EWH + HgCl(2) group. Blood pressure (BP) was indirectly measured and dose-response curves to acetylcholine (ACh), sodium nitroprusside (SNP), and noradrenaline (NE) were assessed in mesenteric resistance arteries (MRA), as in situ production of superoxide anion, nitric oxide (NO) release, vascular reactive oxygen species (ROS), lipid peroxidation, and antioxidant status. Results: Egg white hydrolysate prevented the elevation in BP and the vascular dysfunction after HgCl(2) exposure; restored the NO-mediated endothelial modulation and inhibited the oxidative stress and inflammatory pathways induced by HgCl(2). Conclusion: Egg white hydrolysate seems to be a useful functional food to prevent HgCl(2)-induced vascular toxic effects in MRA. |
format | Online Article Text |
id | pubmed-7714919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77149192020-12-15 Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries Escobar, Alyne Goulart Rizzetti, Danize Aparecida Piagette, Janaina Trindade Peçanha, Franck Maciel Vassallo, Dalton Valentim Miguel, Marta Wiggers, Giulia Alessandra Front Physiol Physiology Aim: We investigated the antioxidant protective power of egg white hydrolysate (EWH) against the vascular damage induced by mercury chloride (HgCl(2)) exposure in resistance arteries. Methods: Male Wistar rats received for 60 days: (I) intramuscular injections (i.m.) of saline and tap water by gavage – Untreated group; (II) 4.6 μg/kg of HgCl(2) i.m. for the first dose and subsequent doses of 0.07 μg/kg/day and tap water by gavage – HgCl(2) group; (III) saline i.m. and 1 g/kg/day of EWH by gavage – EWH group, or (IV) the combination of the HgCl(2) i.m. and EWH by gavage – EWH + HgCl(2) group. Blood pressure (BP) was indirectly measured and dose-response curves to acetylcholine (ACh), sodium nitroprusside (SNP), and noradrenaline (NE) were assessed in mesenteric resistance arteries (MRA), as in situ production of superoxide anion, nitric oxide (NO) release, vascular reactive oxygen species (ROS), lipid peroxidation, and antioxidant status. Results: Egg white hydrolysate prevented the elevation in BP and the vascular dysfunction after HgCl(2) exposure; restored the NO-mediated endothelial modulation and inhibited the oxidative stress and inflammatory pathways induced by HgCl(2). Conclusion: Egg white hydrolysate seems to be a useful functional food to prevent HgCl(2)-induced vascular toxic effects in MRA. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7714919/ /pubmed/33329045 http://dx.doi.org/10.3389/fphys.2020.595767 Text en Copyright © 2020 Escobar, Rizzetti, Piagette, Peçanha, Vassallo, Miguel and Wiggers. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Escobar, Alyne Goulart Rizzetti, Danize Aparecida Piagette, Janaina Trindade Peçanha, Franck Maciel Vassallo, Dalton Valentim Miguel, Marta Wiggers, Giulia Alessandra Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title | Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title_full | Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title_fullStr | Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title_full_unstemmed | Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title_short | Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries |
title_sort | antioxidant properties of egg white hydrolysate prevent mercury-induced vascular damage in resistance arteries |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714919/ https://www.ncbi.nlm.nih.gov/pubmed/33329045 http://dx.doi.org/10.3389/fphys.2020.595767 |
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