Cargando…
The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promotin...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714932/ https://www.ncbi.nlm.nih.gov/pubmed/33329700 http://dx.doi.org/10.3389/fgene.2020.563166 |
_version_ | 1783618836567687168 |
---|---|
author | Dai, Beibei Wang, Feng Nie, Xiang Du, Hengzhi Zhao, Yanru Yin, Zhongwei Li, Huaping Fan, Jiahui Wen, Zheng Wang, Dao Wen Chen, Chen |
author_facet | Dai, Beibei Wang, Feng Nie, Xiang Du, Hengzhi Zhao, Yanru Yin, Zhongwei Li, Huaping Fan, Jiahui Wen, Zheng Wang, Dao Wen Chen, Chen |
author_sort | Dai, Beibei |
collection | PubMed |
description | Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in cardiac fibroblasts. In the vascular system, injuries decrease the endothelial nitric oxide levels and affect the phenotype of vascular smooth muscle cells. Understanding the underlying mechanisms will be helpful for the development of a precise therapeutic approach. Various microRNAs are involved in mediating multiple pathological and physiological processes in the heart. A cardiac enriched microRNA, miR-21, which is essential for cardiac homeostasis, has been demonstrated to act as a cell–cell messenger with diverse functions. This review describes the cell type–specific functions of miR-21 in different cardiovascular diseases and its prospects in clinical therapy. |
format | Online Article Text |
id | pubmed-7714932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77149322020-12-15 The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases Dai, Beibei Wang, Feng Nie, Xiang Du, Hengzhi Zhao, Yanru Yin, Zhongwei Li, Huaping Fan, Jiahui Wen, Zheng Wang, Dao Wen Chen, Chen Front Genet Genetics Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in cardiac fibroblasts. In the vascular system, injuries decrease the endothelial nitric oxide levels and affect the phenotype of vascular smooth muscle cells. Understanding the underlying mechanisms will be helpful for the development of a precise therapeutic approach. Various microRNAs are involved in mediating multiple pathological and physiological processes in the heart. A cardiac enriched microRNA, miR-21, which is essential for cardiac homeostasis, has been demonstrated to act as a cell–cell messenger with diverse functions. This review describes the cell type–specific functions of miR-21 in different cardiovascular diseases and its prospects in clinical therapy. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7714932/ /pubmed/33329700 http://dx.doi.org/10.3389/fgene.2020.563166 Text en Copyright © 2020 Dai, Wang, Nie, Du, Zhao, Yin, Li, Fan, Wen, Wang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Dai, Beibei Wang, Feng Nie, Xiang Du, Hengzhi Zhao, Yanru Yin, Zhongwei Li, Huaping Fan, Jiahui Wen, Zheng Wang, Dao Wen Chen, Chen The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title | The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title_full | The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title_fullStr | The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title_full_unstemmed | The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title_short | The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases |
title_sort | cell type–specific functions of mir-21 in cardiovascular diseases |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714932/ https://www.ncbi.nlm.nih.gov/pubmed/33329700 http://dx.doi.org/10.3389/fgene.2020.563166 |
work_keys_str_mv | AT daibeibei thecelltypespecificfunctionsofmir21incardiovasculardiseases AT wangfeng thecelltypespecificfunctionsofmir21incardiovasculardiseases AT niexiang thecelltypespecificfunctionsofmir21incardiovasculardiseases AT duhengzhi thecelltypespecificfunctionsofmir21incardiovasculardiseases AT zhaoyanru thecelltypespecificfunctionsofmir21incardiovasculardiseases AT yinzhongwei thecelltypespecificfunctionsofmir21incardiovasculardiseases AT lihuaping thecelltypespecificfunctionsofmir21incardiovasculardiseases AT fanjiahui thecelltypespecificfunctionsofmir21incardiovasculardiseases AT wenzheng thecelltypespecificfunctionsofmir21incardiovasculardiseases AT wangdaowen thecelltypespecificfunctionsofmir21incardiovasculardiseases AT chenchen thecelltypespecificfunctionsofmir21incardiovasculardiseases AT daibeibei celltypespecificfunctionsofmir21incardiovasculardiseases AT wangfeng celltypespecificfunctionsofmir21incardiovasculardiseases AT niexiang celltypespecificfunctionsofmir21incardiovasculardiseases AT duhengzhi celltypespecificfunctionsofmir21incardiovasculardiseases AT zhaoyanru celltypespecificfunctionsofmir21incardiovasculardiseases AT yinzhongwei celltypespecificfunctionsofmir21incardiovasculardiseases AT lihuaping celltypespecificfunctionsofmir21incardiovasculardiseases AT fanjiahui celltypespecificfunctionsofmir21incardiovasculardiseases AT wenzheng celltypespecificfunctionsofmir21incardiovasculardiseases AT wangdaowen celltypespecificfunctionsofmir21incardiovasculardiseases AT chenchen celltypespecificfunctionsofmir21incardiovasculardiseases |