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The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases

Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promotin...

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Autores principales: Dai, Beibei, Wang, Feng, Nie, Xiang, Du, Hengzhi, Zhao, Yanru, Yin, Zhongwei, Li, Huaping, Fan, Jiahui, Wen, Zheng, Wang, Dao Wen, Chen, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714932/
https://www.ncbi.nlm.nih.gov/pubmed/33329700
http://dx.doi.org/10.3389/fgene.2020.563166
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author Dai, Beibei
Wang, Feng
Nie, Xiang
Du, Hengzhi
Zhao, Yanru
Yin, Zhongwei
Li, Huaping
Fan, Jiahui
Wen, Zheng
Wang, Dao Wen
Chen, Chen
author_facet Dai, Beibei
Wang, Feng
Nie, Xiang
Du, Hengzhi
Zhao, Yanru
Yin, Zhongwei
Li, Huaping
Fan, Jiahui
Wen, Zheng
Wang, Dao Wen
Chen, Chen
author_sort Dai, Beibei
collection PubMed
description Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in cardiac fibroblasts. In the vascular system, injuries decrease the endothelial nitric oxide levels and affect the phenotype of vascular smooth muscle cells. Understanding the underlying mechanisms will be helpful for the development of a precise therapeutic approach. Various microRNAs are involved in mediating multiple pathological and physiological processes in the heart. A cardiac enriched microRNA, miR-21, which is essential for cardiac homeostasis, has been demonstrated to act as a cell–cell messenger with diverse functions. This review describes the cell type–specific functions of miR-21 in different cardiovascular diseases and its prospects in clinical therapy.
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spelling pubmed-77149322020-12-15 The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases Dai, Beibei Wang, Feng Nie, Xiang Du, Hengzhi Zhao, Yanru Yin, Zhongwei Li, Huaping Fan, Jiahui Wen, Zheng Wang, Dao Wen Chen, Chen Front Genet Genetics Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in cardiac fibroblasts. In the vascular system, injuries decrease the endothelial nitric oxide levels and affect the phenotype of vascular smooth muscle cells. Understanding the underlying mechanisms will be helpful for the development of a precise therapeutic approach. Various microRNAs are involved in mediating multiple pathological and physiological processes in the heart. A cardiac enriched microRNA, miR-21, which is essential for cardiac homeostasis, has been demonstrated to act as a cell–cell messenger with diverse functions. This review describes the cell type–specific functions of miR-21 in different cardiovascular diseases and its prospects in clinical therapy. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7714932/ /pubmed/33329700 http://dx.doi.org/10.3389/fgene.2020.563166 Text en Copyright © 2020 Dai, Wang, Nie, Du, Zhao, Yin, Li, Fan, Wen, Wang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Dai, Beibei
Wang, Feng
Nie, Xiang
Du, Hengzhi
Zhao, Yanru
Yin, Zhongwei
Li, Huaping
Fan, Jiahui
Wen, Zheng
Wang, Dao Wen
Chen, Chen
The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title_full The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title_fullStr The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title_full_unstemmed The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title_short The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases
title_sort cell type–specific functions of mir-21 in cardiovascular diseases
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714932/
https://www.ncbi.nlm.nih.gov/pubmed/33329700
http://dx.doi.org/10.3389/fgene.2020.563166
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