Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patien...

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Autores principales: Van Damme, Karel F. A., Tavernier, Simon, Van Roy, Nele, De Leeuw, Elisabeth, Declercq, Jozefien, Bosteels, Cédric, Maes, Bastiaan, De Bruyne, Marieke, Bogaert, Delfien, Bosteels, Victor, Hoste, Levi, Naesens, Leslie, Maes, Piet, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Depuydt, Pieter, Van Braeckel, Eva, Haerynck, Filomeen, Lambrecht, Bart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714937/
https://www.ncbi.nlm.nih.gov/pubmed/33329586
http://dx.doi.org/10.3389/fimmu.2020.596761
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author Van Damme, Karel F. A.
Tavernier, Simon
Van Roy, Nele
De Leeuw, Elisabeth
Declercq, Jozefien
Bosteels, Cédric
Maes, Bastiaan
De Bruyne, Marieke
Bogaert, Delfien
Bosteels, Victor
Hoste, Levi
Naesens, Leslie
Maes, Piet
Grifoni, Alba
Weiskopf, Daniela
Sette, Alessandro
Depuydt, Pieter
Van Braeckel, Eva
Haerynck, Filomeen
Lambrecht, Bart N.
author_facet Van Damme, Karel F. A.
Tavernier, Simon
Van Roy, Nele
De Leeuw, Elisabeth
Declercq, Jozefien
Bosteels, Cédric
Maes, Bastiaan
De Bruyne, Marieke
Bogaert, Delfien
Bosteels, Victor
Hoste, Levi
Naesens, Leslie
Maes, Piet
Grifoni, Alba
Weiskopf, Daniela
Sette, Alessandro
Depuydt, Pieter
Van Braeckel, Eva
Haerynck, Filomeen
Lambrecht, Bart N.
author_sort Van Damme, Karel F. A.
collection PubMed
description The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.
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spelling pubmed-77149372020-12-15 Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19 Van Damme, Karel F. A. Tavernier, Simon Van Roy, Nele De Leeuw, Elisabeth Declercq, Jozefien Bosteels, Cédric Maes, Bastiaan De Bruyne, Marieke Bogaert, Delfien Bosteels, Victor Hoste, Levi Naesens, Leslie Maes, Piet Grifoni, Alba Weiskopf, Daniela Sette, Alessandro Depuydt, Pieter Van Braeckel, Eva Haerynck, Filomeen Lambrecht, Bart N. Front Immunol Immunology The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7714937/ /pubmed/33329586 http://dx.doi.org/10.3389/fimmu.2020.596761 Text en Copyright © 2020 Van Damme, Tavernier, Van Roy, De Leeuw, Declercq, Bosteels, Maes, De Bruyne, Bogaert, Bosteels, Hoste, Naesens, Maes, Grifoni, Weiskopf, Sette, Depuydt, Van Braeckel, Haerynck and Lambrecht http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Van Damme, Karel F. A.
Tavernier, Simon
Van Roy, Nele
De Leeuw, Elisabeth
Declercq, Jozefien
Bosteels, Cédric
Maes, Bastiaan
De Bruyne, Marieke
Bogaert, Delfien
Bosteels, Victor
Hoste, Levi
Naesens, Leslie
Maes, Piet
Grifoni, Alba
Weiskopf, Daniela
Sette, Alessandro
Depuydt, Pieter
Van Braeckel, Eva
Haerynck, Filomeen
Lambrecht, Bart N.
Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title_full Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title_fullStr Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title_full_unstemmed Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title_short Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
title_sort case report: convalescent plasma, a targeted therapy for patients with cvid and severe covid-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714937/
https://www.ncbi.nlm.nih.gov/pubmed/33329586
http://dx.doi.org/10.3389/fimmu.2020.596761
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