Small interfering RNA for cancer treatment: overcoming hurdles in delivery

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. Th...

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Autores principales: Charbe, Nitin Bharat, Amnerkar, Nikhil D., Ramesh, B., Tambuwala, Murtaza M., Bakshi, Hamid A., Aljabali, Alaa A.A., Khadse, Saurabh C., Satheeshkumar, Rajendran, Satija, Saurabh, Metha, Meenu, Chellappan, Dinesh Kumar, Shrivastava, Garima, Gupta, Gaurav, Negi, Poonam, Dua, Kamal, Zacconi, Flavia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714980/
https://www.ncbi.nlm.nih.gov/pubmed/33304780
http://dx.doi.org/10.1016/j.apsb.2020.10.005
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author Charbe, Nitin Bharat
Amnerkar, Nikhil D.
Ramesh, B.
Tambuwala, Murtaza M.
Bakshi, Hamid A.
Aljabali, Alaa A.A.
Khadse, Saurabh C.
Satheeshkumar, Rajendran
Satija, Saurabh
Metha, Meenu
Chellappan, Dinesh Kumar
Shrivastava, Garima
Gupta, Gaurav
Negi, Poonam
Dua, Kamal
Zacconi, Flavia C.
author_facet Charbe, Nitin Bharat
Amnerkar, Nikhil D.
Ramesh, B.
Tambuwala, Murtaza M.
Bakshi, Hamid A.
Aljabali, Alaa A.A.
Khadse, Saurabh C.
Satheeshkumar, Rajendran
Satija, Saurabh
Metha, Meenu
Chellappan, Dinesh Kumar
Shrivastava, Garima
Gupta, Gaurav
Negi, Poonam
Dua, Kamal
Zacconi, Flavia C.
author_sort Charbe, Nitin Bharat
collection PubMed
description In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.
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spelling pubmed-77149802020-12-09 Small interfering RNA for cancer treatment: overcoming hurdles in delivery Charbe, Nitin Bharat Amnerkar, Nikhil D. Ramesh, B. Tambuwala, Murtaza M. Bakshi, Hamid A. Aljabali, Alaa A.A. Khadse, Saurabh C. Satheeshkumar, Rajendran Satija, Saurabh Metha, Meenu Chellappan, Dinesh Kumar Shrivastava, Garima Gupta, Gaurav Negi, Poonam Dua, Kamal Zacconi, Flavia C. Acta Pharm Sin B Review In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies. Elsevier 2020-11 2020-10-13 /pmc/articles/PMC7714980/ /pubmed/33304780 http://dx.doi.org/10.1016/j.apsb.2020.10.005 Text en © 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Charbe, Nitin Bharat
Amnerkar, Nikhil D.
Ramesh, B.
Tambuwala, Murtaza M.
Bakshi, Hamid A.
Aljabali, Alaa A.A.
Khadse, Saurabh C.
Satheeshkumar, Rajendran
Satija, Saurabh
Metha, Meenu
Chellappan, Dinesh Kumar
Shrivastava, Garima
Gupta, Gaurav
Negi, Poonam
Dua, Kamal
Zacconi, Flavia C.
Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title_full Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title_fullStr Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title_full_unstemmed Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title_short Small interfering RNA for cancer treatment: overcoming hurdles in delivery
title_sort small interfering rna for cancer treatment: overcoming hurdles in delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714980/
https://www.ncbi.nlm.nih.gov/pubmed/33304780
http://dx.doi.org/10.1016/j.apsb.2020.10.005
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