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ATRT-17. TARGETING GLUTAMINE METABOLISM LOWERS METHYLATION POTENCIALS IN AT/RT AND SYNERGIZE WITH TAZEMETOSTAT
Atypical teratoid/rhabdoid tumors (AT/RT) have a single recurring genetic mutation in SMARCB1. This deletion leads to an abnormal SWI/SNF chromatin remodeling complex and the constitutive activation of EZH2. S-adenosyl-L-methionine (SAM) donates a methyl group to EZH2 which then methylates DNA and h...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715146/ http://dx.doi.org/10.1093/neuonc/noaa222.016 |