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LGG-17. SYNERGISTIC ACTIVITY OF MAPK INHIBITOR CLASSES REVEALED BY A NOVEL CELL-BASED MAPK ACTIVITY PEDIATRIC LOW-GRADE GLIOMA ASSAY

Pilocytic astrocytomas (PAs) and other pediatric low-grade gliomas (pLGGs) exhibit aberrant activation of the MAPK signaling pathway caused by genetic alterations, most commonly KIAA1549:BRAF fusions, BRAF V600E and NF1 mutations. In such a single-pathway disease, novel drugs targeting the MAPK path...

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Detalles Bibliográficos
Autores principales:	Usta, Diren, Sigaud, Romain, Buhl, Juliane L, Selt, Florian, Marquardt, Viktoria, Pauck, David, Pusch, Stefan, Ecker, Jonas, Hielscher, Thomas, Vollmer, Johanna, Sommerkamp, Alexander C, Rubner, Tobias, Hargrave, Darren, van Tilburg, Cornelis M, Pfister, Stefan M, Jones, David T W, Remke, Marc, Brummer, Tilman, Witt, Olaf, Milde, Till
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Low Grade Glioma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715150/ http://dx.doi.org/10.1093/neuonc/noaa222.399

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