DIPG-14. TARGETING POLO-LIKE KINASE 1 IN COMBINATION WITH KEY ONCOGENIC DRIVERS IN DIPG: FROM SINGLE AGENT TO COMBINATION STRATEGIES

Diffuse Intrinsic Pontine Glioma (DIPG) are devastating paediatric brainstem tumours. Loss of function mutations in DIPG decrease genetic stability and impair DNA damage response pathways promoting tumourigenesis. Polo-like Kinase 1 (PLK1) is a pivotal controller of cell growth, regulating key inter...

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Detalles Bibliográficos
Autores principales: Franshaw, Laura, Hayden, Elisha, Joshi, Swapna, Liu, Jie, Ehteda, Anahid, Pang, Chi Nam Ignatius, Tsoli, Maria, Ziegler, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715152/
http://dx.doi.org/10.1093/neuonc/noaa222.064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715152/
http://dx.doi.org/10.1093/neuonc/noaa222.064

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