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DDEL-14. SAFETY OF INTERVENTRICULAR METHOTREXATE ADMINISTRATION FOLLOWING RADIATION IN PEDIATRIC PATIENTS WITH MALIGNANT BRAIN TUMORS

BACKGROUND: Methotrexate has been used for intrathecal administration in leukemia as well as embryonal CNS tumors in children. Concerns about neurologic side effects including leukoencephalopathy, demyelination, and seizures have limited the use of methotrexate following exposure to focal radiation....

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Detalles Bibliográficos
Autores principales:	Rosales, Kristofer, Maher, Ossama, Fader, Maggie, Gallegos, Natalie, Niazi, Toba, Ragheb, John, Khatib, Ziad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Drug Delivery/Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715178/ http://dx.doi.org/10.1093/neuonc/noaa222.049

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