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ATRT-01. UPREGULATION OF PROTEIN SYNTHESIS AND PROTEASOME DEGRADATION CONFERS SENSITIVITY TO PROTEASOME INHIBITOR BORTEZOMIB IN MYC-ATYPICAL TERATOID/RHABDOID TUMORS

BACKGROUND: Atypical teratoid rhabdoid tumors (ATRTs) are among the most malignant brain tumors in early childhood and remain incurable. Myc-ATRT is driven by the Myc oncogene, which directly controls the intracellular protein synthesis rate. Proteasome inhibitor bortezomib (BTZ) was approved by the...

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Detalles Bibliográficos
Autores principales:	Tran, Minh-Huy, Wu, Kuo-Sheng, Chang, Che-Chang, Wong, Tai-Tong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Atypical Teratoid/Rhabdoid Tumors
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715207/ http://dx.doi.org/10.1093/neuonc/noaa222.001

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