LGG-15. PEDIATRIC LOW-GRADE GLIOMAS IN SAUDI ARABIA: RETROSPECTIVE ANALYSIS OF CHILDREN WITH LOW-GRADE GLIOMAS TREATED IN KING FAHAD MEDICAL CITY KFMC- SINGLE INSTITUTIONAL EXPERIENCE

Pediatric Low-grade gliomas (PLGGs) are extremely heterogeneous tumors and account for approximately 35% of childhood brain tumors. This retrospective study on 55 newly diagnosed children (<14 ys) with pathologically confirmed LGG from 2006 to 2016 aimed to review demographic data, clinical and therapeutic aspects and treatment outcome of PLGGs in children in Saudi Arabia. RESULTS: 33 (60.0%) males,22 (40.0%) females, median age at diagnosis 68 months. Pilocytic astrocytoma was the most common pathological diagnosis 42 (76.4%) location of tumor was Infratentorial in 30 patients (54.0%) and Supratentorial in 24 patients (43.2%), 19 patients (34.6%) had total surgical excision, 10 (18.2%) subtotal resection, 20 (36.4%) partial excision and 6 (10.9%) had biopsy only; After initial Surgery 30 patients (54.5%) required adjuvant chemotherapy of whom 14 patients (46.7%) experienced a treatment failure event, 25 patients (45.5%) who were initially observed post surgery 6 patients (24%) of them had relapse /progression and required further therapy. Only 2 patients (3.6%) received radiotherapy due to uncontrolled progression first line chemotherapy carboplatin and vincristine (CV) regimen was tolerated, Carboplatin allergic reactions developed in 21.1% of patients. Median follow-up of 6.49 years, the median time of relapse/ progression was 2.85 years The 5-year overall survival (OS) rates and progression free survival for all patients were 92.2 %, and 63.3% respectively. This study was to document the outcome of pediatric LGG in Saudi Arabia and to serve as a guideline for the future management with incorporation of molecular studies on pediatric LGGs which may help improve the outcome for Saudi children with LGG.