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DIPG-43. CAN WE REPROGRAM DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)? EXPLORING THE ROLE OF DISTALLESS/DLX HOMEOBOX GENE REGULATION OF OLIGODENDROGLIAL PROGENITOR CELLS (OPC) IN THE DEVELOPING VERTEBRATE NERVOUS SYSTEM

BACKGROUND: The identification of H3.3/H3.1K27M in most DIPG has changed our understanding of this disease. H3K27M mutations usually demonstrate global loss of H3K27 trimethylation (me(3)) with gain of H3K27 acetylation (ac). Single cell RNAseq has identified the putative cell of origin as oligodend...

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Detalles Bibliográficos
Autores principales:	Nevin, Mikaela, Gallego, Janine, Song, Xiaohua, Jiang, Qiang, Underhill, Alan, Godbout, Roseline, Becher, Oren, Eisenstat, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Diffuse Midline Glioma/DIPG
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715303/ http://dx.doi.org/10.1093/neuonc/noaa222.090

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