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DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL

OBJECTIVE: This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS: Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter inser...

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Detalles Bibliográficos
Autores principales:	Sirianni, Rachael W, Kharas, Natasha, Yu, Bangning, Janssen, Christopher F, Trimble, Amanda, Ballester, Leomar Y, Patel, Rajan, Mohammad, Afroz S, Elmquist, William F, Sandberg, David I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Drug Delivery/Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715323/ http://dx.doi.org/10.1093/neuonc/noaa222.044

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