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COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY
BACKGROUND: The GCCCR is a collaboration between SIOP and SJCRH to describe the natural history of SARS-CoV-2 in children with cancer across the world. METHODS: The GCCCR is a deidentified registry of patients <19 years of age with cancer or recipients of a hematopoietic stem cell transplant and...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715335/ http://dx.doi.org/10.1093/neuonc/noaa222.035 |
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author | Moreira, Daniel Bouffet, Eric Bhakta, Nickhill Chantada, Guillermo Chen, Yichen Faughnan, Lane Vedaraju, Yuvanesh Avula, Maghana Homsi, Maysam Naidu, Paula Pappas, Andrew Ranadive, Radhikesh Santana, Victor Sullivan, Michael Baroni, Lorena Caniza, Miguela Devidas, Meenakshi Pritchard-Jones, Kathy Rodriguez-Galindo, Carlos Mukkada, Sheena |
author_facet | Moreira, Daniel Bouffet, Eric Bhakta, Nickhill Chantada, Guillermo Chen, Yichen Faughnan, Lane Vedaraju, Yuvanesh Avula, Maghana Homsi, Maysam Naidu, Paula Pappas, Andrew Ranadive, Radhikesh Santana, Victor Sullivan, Michael Baroni, Lorena Caniza, Miguela Devidas, Meenakshi Pritchard-Jones, Kathy Rodriguez-Galindo, Carlos Mukkada, Sheena |
author_sort | Moreira, Daniel |
collection | PubMed |
description | BACKGROUND: The GCCCR is a collaboration between SIOP and SJCRH to describe the natural history of SARS-CoV-2 in children with cancer across the world. METHODS: The GCCCR is a deidentified registry of patients <19 years of age with cancer or recipients of a hematopoietic stem cell transplant and laboratory-confirmed SARS-CoV-2 infection. Demographic data, cancer diagnosis, cancer-directed therapy, and clinical characteristics of SARS-CoV-2 infection were collected. Outcomes were collected at 30-days and 60-days post infection. RESULTS: As of August 10(th) 2020, the GCCCR included 730 cases from 35 countries, including 64 children with CNS tumors (8.8%) from 17 countries. The most frequent diagnoses were embryonal tumors (31.2%) and low-grade glioma (17.2%). Thirty-nine (60.9%) children were asymptomatic from infection, while 19 (29.7%) patients required hospital admission and 2 (6.3%) transferred to the intensive care unit. There was a significant association between infection severity and ANC <500 (p=0.04). At the time of infection, 44 (68.8%) patients were undergoing cancer-directed therapy. Thirty-two cases have follow-up data. No modification in cancer-directed therapy occurred in 11 (34.4%) patients, while chemotherapy was modified in 6 (18.8%), radiotherapy delayed in 2 (6.3%), and surgery postponed in 1 (3.1%). No patients died from SARS-CoV-2 infection, although 2 died from non-COVID-19 related causes. CONCLUSION: The frequency and severity of COVID infection among children with CNS tumors appears to be proportionally lower compared to other children with cancer. Although this is the largest cohort of patients reported to date, additional insight is needed, including the effects of treatment modifications on outcomes. |
format | Online Article Text |
id | pubmed-7715335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77153352020-12-09 COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY Moreira, Daniel Bouffet, Eric Bhakta, Nickhill Chantada, Guillermo Chen, Yichen Faughnan, Lane Vedaraju, Yuvanesh Avula, Maghana Homsi, Maysam Naidu, Paula Pappas, Andrew Ranadive, Radhikesh Santana, Victor Sullivan, Michael Baroni, Lorena Caniza, Miguela Devidas, Meenakshi Pritchard-Jones, Kathy Rodriguez-Galindo, Carlos Mukkada, Sheena Neuro Oncol COVID-19 and Pediatric Neuro-Oncology BACKGROUND: The GCCCR is a collaboration between SIOP and SJCRH to describe the natural history of SARS-CoV-2 in children with cancer across the world. METHODS: The GCCCR is a deidentified registry of patients <19 years of age with cancer or recipients of a hematopoietic stem cell transplant and laboratory-confirmed SARS-CoV-2 infection. Demographic data, cancer diagnosis, cancer-directed therapy, and clinical characteristics of SARS-CoV-2 infection were collected. Outcomes were collected at 30-days and 60-days post infection. RESULTS: As of August 10(th) 2020, the GCCCR included 730 cases from 35 countries, including 64 children with CNS tumors (8.8%) from 17 countries. The most frequent diagnoses were embryonal tumors (31.2%) and low-grade glioma (17.2%). Thirty-nine (60.9%) children were asymptomatic from infection, while 19 (29.7%) patients required hospital admission and 2 (6.3%) transferred to the intensive care unit. There was a significant association between infection severity and ANC <500 (p=0.04). At the time of infection, 44 (68.8%) patients were undergoing cancer-directed therapy. Thirty-two cases have follow-up data. No modification in cancer-directed therapy occurred in 11 (34.4%) patients, while chemotherapy was modified in 6 (18.8%), radiotherapy delayed in 2 (6.3%), and surgery postponed in 1 (3.1%). No patients died from SARS-CoV-2 infection, although 2 died from non-COVID-19 related causes. CONCLUSION: The frequency and severity of COVID infection among children with CNS tumors appears to be proportionally lower compared to other children with cancer. Although this is the largest cohort of patients reported to date, additional insight is needed, including the effects of treatment modifications on outcomes. Oxford University Press 2020-12-04 /pmc/articles/PMC7715335/ http://dx.doi.org/10.1093/neuonc/noaa222.035 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | COVID-19 and Pediatric Neuro-Oncology Moreira, Daniel Bouffet, Eric Bhakta, Nickhill Chantada, Guillermo Chen, Yichen Faughnan, Lane Vedaraju, Yuvanesh Avula, Maghana Homsi, Maysam Naidu, Paula Pappas, Andrew Ranadive, Radhikesh Santana, Victor Sullivan, Michael Baroni, Lorena Caniza, Miguela Devidas, Meenakshi Pritchard-Jones, Kathy Rodriguez-Galindo, Carlos Mukkada, Sheena COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title | COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title_full | COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title_fullStr | COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title_full_unstemmed | COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title_short | COVD-04. CHARACTERISTICS OF SARS-COV-2 IN 64 CHILDREN WITH CNS TUMORS: A REPORT FROM THE SIOP/ST. JUDE CHILDREN’S RESEARCH HOSPITAL (SJCRH) GLOBAL COVID-19 CHILDHOOD CANCER REGISTRY |
title_sort | covd-04. characteristics of sars-cov-2 in 64 children with cns tumors: a report from the siop/st. jude children’s research hospital (sjcrh) global covid-19 childhood cancer registry |
topic | COVID-19 and Pediatric Neuro-Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715335/ http://dx.doi.org/10.1093/neuonc/noaa222.035 |
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