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TBIO-14. CHARACTERISATION OF THE ARGININE PATHWAY ENZYMES IN PAEDIATRIC BRAIN TUMOURS TO DETERMINE SUSCEPTIBILITY TO THERAPEUTIC ARGININE DEPLETION

INTRODUCTION: Extracellular arginine dependency (auxotrophy) is increasingly being recognised in several tumours. This is due to the inability of cancer cells to recycle or synthesise intracellular arginine through the urea cycle pathway compared to normal cells. Whilst adult glioblastoma is known t...

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Detalles Bibliográficos
Autores principales:	Bishop, Eleanor, Dimitrova, Monika, Storer, Lisa, Grundy, Richard, Dandapani, Madhumita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Tumor Biology (not fitting a specific disease category)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715343/ http://dx.doi.org/10.1093/neuonc/noaa222.841

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