Cargando…
GCT-75. ISOLATED PITUITARY STALK THICKENING
OBJECTIVES: Only few studies have examined the predictive factors and outcome of isolated pituitary stalk thickening (PST) in children. We aim to describe our institutional cohort to determine predictors of future malignancy. METHODS: A search of the radiology, endocrinology and neuro-oncology datab...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715351/ http://dx.doi.org/10.1093/neuonc/noaa222.291 |
_version_ | 1783618935495589888 |
---|---|
author | Bennett, Julie Nobre, Liana Bouffet, Eric Abla, Oussama Wasserman, Jonathan Ertl-Wagner, Birgit Bartels, Ute |
author_facet | Bennett, Julie Nobre, Liana Bouffet, Eric Abla, Oussama Wasserman, Jonathan Ertl-Wagner, Birgit Bartels, Ute |
author_sort | Bennett, Julie |
collection | PubMed |
description | OBJECTIVES: Only few studies have examined the predictive factors and outcome of isolated pituitary stalk thickening (PST) in children. We aim to describe our institutional cohort to determine predictors of future malignancy. METHODS: A search of the radiology, endocrinology and neuro-oncology databases was performed to identify patients with isolated PST diagnosed between January 2000 and June 2019. Clinical data was collected. A detailed radiology review of baseline and follow up magnetic resonance imaging (MRI) was undertaken in a blinded fashion by two examiners. RESULTS: Forty-four patients were identified, with 37 meeting criteria for isolated PST and adequate imaging. Median age of baseline MRI was 9.9 years (range 0.9–17.5). Twenty-three were female (62%). Median follow up time was 5 (0.31–18.6) years. Indication for MRI was symptoms of diabetes insipidus (DI) in 28 patients with the remainder having other concerns for endocrine disturbance (7), headache (1) or visual impairment (1). Thirty-five subjects had pituitary dysfunction (95%), including 30 with diabetes insipidus (81%). Nine patients developed a malignancy (24%), with germinoma (5), Langerhans cell histiocytosis (3) and lymphoma (1) at a median of 0.36 years, 0.63 years and 1.1 years respectively. Elevated white blood cell count (>5 x 10(6)/L) in initial cerebrospinal fluid analysis was predictive of future diagnosis of germinoma or lymphoma (p=0.027). CONCLUSION: In this cohort 24% of children with PST were eventually diagnosed with a neoplasia after a median of 0.63 years. Pleocytosis in initial CSF samples was predictive for future development of germinoma or lymphoma. |
format | Online Article Text |
id | pubmed-7715351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77153512020-12-09 GCT-75. ISOLATED PITUITARY STALK THICKENING Bennett, Julie Nobre, Liana Bouffet, Eric Abla, Oussama Wasserman, Jonathan Ertl-Wagner, Birgit Bartels, Ute Neuro Oncol Germ Cell Tumors OBJECTIVES: Only few studies have examined the predictive factors and outcome of isolated pituitary stalk thickening (PST) in children. We aim to describe our institutional cohort to determine predictors of future malignancy. METHODS: A search of the radiology, endocrinology and neuro-oncology databases was performed to identify patients with isolated PST diagnosed between January 2000 and June 2019. Clinical data was collected. A detailed radiology review of baseline and follow up magnetic resonance imaging (MRI) was undertaken in a blinded fashion by two examiners. RESULTS: Forty-four patients were identified, with 37 meeting criteria for isolated PST and adequate imaging. Median age of baseline MRI was 9.9 years (range 0.9–17.5). Twenty-three were female (62%). Median follow up time was 5 (0.31–18.6) years. Indication for MRI was symptoms of diabetes insipidus (DI) in 28 patients with the remainder having other concerns for endocrine disturbance (7), headache (1) or visual impairment (1). Thirty-five subjects had pituitary dysfunction (95%), including 30 with diabetes insipidus (81%). Nine patients developed a malignancy (24%), with germinoma (5), Langerhans cell histiocytosis (3) and lymphoma (1) at a median of 0.36 years, 0.63 years and 1.1 years respectively. Elevated white blood cell count (>5 x 10(6)/L) in initial cerebrospinal fluid analysis was predictive of future diagnosis of germinoma or lymphoma (p=0.027). CONCLUSION: In this cohort 24% of children with PST were eventually diagnosed with a neoplasia after a median of 0.63 years. Pleocytosis in initial CSF samples was predictive for future development of germinoma or lymphoma. Oxford University Press 2020-12-04 /pmc/articles/PMC7715351/ http://dx.doi.org/10.1093/neuonc/noaa222.291 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Germ Cell Tumors Bennett, Julie Nobre, Liana Bouffet, Eric Abla, Oussama Wasserman, Jonathan Ertl-Wagner, Birgit Bartels, Ute GCT-75. ISOLATED PITUITARY STALK THICKENING |
title | GCT-75. ISOLATED PITUITARY STALK THICKENING |
title_full | GCT-75. ISOLATED PITUITARY STALK THICKENING |
title_fullStr | GCT-75. ISOLATED PITUITARY STALK THICKENING |
title_full_unstemmed | GCT-75. ISOLATED PITUITARY STALK THICKENING |
title_short | GCT-75. ISOLATED PITUITARY STALK THICKENING |
title_sort | gct-75. isolated pituitary stalk thickening |
topic | Germ Cell Tumors |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715351/ http://dx.doi.org/10.1093/neuonc/noaa222.291 |
work_keys_str_mv | AT bennettjulie gct75isolatedpituitarystalkthickening AT nobreliana gct75isolatedpituitarystalkthickening AT bouffeteric gct75isolatedpituitarystalkthickening AT ablaoussama gct75isolatedpituitarystalkthickening AT wassermanjonathan gct75isolatedpituitarystalkthickening AT ertlwagnerbirgit gct75isolatedpituitarystalkthickening AT bartelsute gct75isolatedpituitarystalkthickening |